UNITED STATES
                       SECURITIES AND EXCHANGE COMMISSION
                             WASHINGTON, D.C. 20549


                                  SCHEDULE 13G

                    UNDER THE SECURITIES EXCHANGE ACT OF 1934
                               (AMENDMENT NO. 1)*

                                  Nuvelo, Inc.
--------------------------------------------------------------------------------
                                (Name of Issuer)

                                  Common Stock
--------------------------------------------------------------------------------
                         (Title of Class of Securities)

                                    67072M103
                                    ---------
                                 (CUSIP Number)

                                December 31, 2005
                                -----------------
                      (Date of Event which Requires Filing
                               of this Statement)



Check the appropriate box to designate the rule pursuant to which this Schedule
is filed:

                  [ ]      Rule 13d-1(b)
                  [X]      Rule 13d-1(c)
                  [ ]      Rule 13d-1(d)



  *The remainder of this cover page shall be filled out for a reporting person's
  initial filing on this form with respect to the subject class of securities,
  and for any subsequent amendment containing information which would alter the
  disclosures provided in a prior cover page.

  The information required on the remainder of this cover page shall not be
  deemed to be "filed" for the purpose of Section 18 of the Securities Exchange
  Act of 1934 ("Act") or otherwise subject to the liabilities of that section of
  the Act but shall be subject to all other provisions of the Act (however, see
  the Notes).



                                  Page 1 of 11




----------------------                                   ----------------------
CUSIP No. 67072M103                    13G               Page 2 of 11 Pages
----------------------                                   ----------------------

--------------------------------------------------------------------------------
        1  NAME OF REPORTING PERSON
           I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

           S.A.C. Capital Advisors, LLC
--------------------------------------------------------------------------------
        2  CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*
                                                                   (a) /_/
                                                                   (b) /x/
--------------------------------------------------------------------------------
        3  SEC USE ONLY

--------------------------------------------------------------------------------
        4  CITIZENSHIP OR PLACE OF ORGANIZATION

           Delaware
--------------------------------------------------------------------------------
      NUMBER OF          5  SOLE VOTING POWER
        SHARES
     BENEFICIALLY           0
        OWNED         ----------------------------------------------------------
          BY             6  SHARED VOTING POWER
         EACH
      REPORTING             0 (see Item 4)
        PERSON        ----------------------------------------------------------
         WITH            7  SOLE DISPOSITIVE POWER

                            0
                      ----------------------------------------------------------
                         8  SHARED DISPOSITIVE POWER

                            0 (see Item 4)
--------------------------------------------------------------------------------
        9  AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

           0 (see Item 4)
--------------------------------------------------------------------------------
       10  CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES

           / /
--------------------------------------------------------------------------------
       11  PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)

           0% (see Item 4)
--------------------------------------------------------------------------------
       12  TYPE OF REPORTING PERSON*

           00
--------------------------------------------------------------------------------

                       *SEE INSTRUCTION BEFORE FILLING OUT

                                  Page 2 of 11




----------------------                                   ----------------------
CUSIP No. 67072M103                    13G               Page 3 of 11 Pages
----------------------                                   ----------------------

--------------------------------------------------------------------------------
        1  NAME OF REPORTING PERSON
           I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

           S.A.C. Capital Management, LLC
--------------------------------------------------------------------------------
        2  CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*
                                                                   (a) /_/
                                                                   (b) /x/
--------------------------------------------------------------------------------
        3  SEC USE ONLY

--------------------------------------------------------------------------------
        4  CITIZENSHIP OR PLACE OF ORGANIZATION

           Delaware
--------------------------------------------------------------------------------
      NUMBER OF          5  SOLE VOTING POWER
       SHARES
    BENEFICIALLY            0
        OWNED        -----------------------------------------------------------
         BY              6  SHARED VOTING POWER
        EACH
      REPORTING             0 (see Item 4)
       PERSON        -----------------------------------------------------------
        WITH             7  SOLE DISPOSITIVE POWER

                            0
                     -----------------------------------------------------------
                         8  SHARED DISPOSITIVE POWER

                            0 (see Item 4)
--------------------------------------------------------------------------------
        9  AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

           0 (see Item 4)
--------------------------------------------------------------------------------
       10  CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES

           / /
--------------------------------------------------------------------------------
       11  PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)

           0% (see Item 4)
--------------------------------------------------------------------------------
       12  TYPE OF REPORTING PERSON*

           00
--------------------------------------------------------------------------------

                       *SEE INSTRUCTION BEFORE FILLING OUT

                                  Page 3 of 11




----------------------                                   ----------------------
CUSIP No. 67072M103                    13G               Page 4 of 11 Pages
----------------------                                   ----------------------

--------------------------------------------------------------------------------
        1  NAME OF REPORTING PERSON
           I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

           Sigma Capital Management, LLC
--------------------------------------------------------------------------------
        2  CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*
                                                                  (a) /_/
                                                                  (b) /x/
--------------------------------------------------------------------------------
        3  SEC USE ONLY

--------------------------------------------------------------------------------
        4  CITIZENSHIP OR PLACE OF ORGANIZATION

           Delaware
--------------------------------------------------------------------------------
      NUMBER OF          5  SOLE VOTING POWER
       SHARES
    BENEFICIALLY            0
        OWNED        -----------------------------------------------------------
         BY              6  SHARED VOTING POWER
        EACH
      REPORTING             3,655,033 (see Item 4)
       PERSON        -----------------------------------------------------------
        WITH             7  SOLE DISPOSITIVE POWER

                            0
                     -----------------------------------------------------------
                         8  SHARED DISPOSITIVE POWER

                            3,655,033 (see Item 4)
--------------------------------------------------------------------------------
        9  AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

           3,655,033 (see Item 4)
--------------------------------------------------------------------------------
       10  CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES

           / /
--------------------------------------------------------------------------------
       11  PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)

           8.6% (see Item 4)
--------------------------------------------------------------------------------
       12  TYPE OF REPORTING PERSON*

           00
--------------------------------------------------------------------------------
                       *SEE INSTRUCTION BEFORE FILLING OUT


                                  Page 4 of 11




----------------------                                   ----------------------
CUSIP No. 67072M103                    13G               Page 5 of 11 Pages
----------------------                                   ----------------------

--------------------------------------------------------------------------------
        1  NAME OF REPORTING PERSON
           I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

           Sigma Capital Associates, LLC
--------------------------------------------------------------------------------
        2  CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*
                                                                  (a) /_/
                                                                  (b) /x/
--------------------------------------------------------------------------------
        3  SEC USE ONLY

--------------------------------------------------------------------------------
        4  CITIZENSHIP OR PLACE OF ORGANIZATION

           Anguilla, British West Indies
--------------------------------------------------------------------------------
      NUMBER OF          5  SOLE VOTING POWER
       SHARES
    BENEFICIALLY            0
        OWNED        -----------------------------------------------------------
         BY              6  SHARED VOTING POWER
        EACH
      REPORTING             3,655,033 (see Item 4)
       PERSON        -----------------------------------------------------------
        WITH             7  SOLE DISPOSITIVE POWER

                            0
                     -----------------------------------------------------------
                         8  SHARED DISPOSITIVE POWER

                            3,655,033 (see Item 4)
--------------------------------------------------------------------------------
        9  AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

           3,655,033 (see Item 4)
--------------------------------------------------------------------------------
       10  CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES

           / /
--------------------------------------------------------------------------------
       11  PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)

           8.6% (see Item 4)
--------------------------------------------------------------------------------
       12  TYPE OF REPORTING PERSON*

           00
--------------------------------------------------------------------------------
                       *SEE INSTRUCTION BEFORE FILLING OUT

                                  Page 5 of 11




----------------------                                   ----------------------
CUSIP No. 67072M103                    13G               Page 6 of 11 Pages
----------------------                                   ----------------------

--------------------------------------------------------------------------------
        1  NAME OF REPORTING PERSON
           I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

           Steven A. Cohen
--------------------------------------------------------------------------------
        2  CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*
                                                                   (a) /_/
                                                                   (b) /x/
--------------------------------------------------------------------------------
        3  SEC USE ONLY

--------------------------------------------------------------------------------
        4  CITIZENSHIP OR PLACE OF ORGANIZATION

           United States
--------------------------------------------------------------------------------
      NUMBER OF          5  SOLE VOTING POWER
       SHARES
    BENEFICIALLY            0
        OWNED        -----------------------------------------------------------
         BY              6  SHARED VOTING POWER
        EACH
      REPORTING             3,655,033 (see Item 4)
       PERSON        -----------------------------------------------------------
        WITH             7  SOLE DISPOSITIVE POWER

                            0
                     -----------------------------------------------------------
                         8  SHARED DISPOSITIVE POWER

                            3,655,033 (see Item 4)
--------------------------------------------------------------------------------
        9  AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

           3,655,033 (see Item 4)
--------------------------------------------------------------------------------
       10  CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES

           / /
--------------------------------------------------------------------------------
       11  PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)

           8.6% (see Item 4)
--------------------------------------------------------------------------------
       12  TYPE OF REPORTING PERSON*

           IN
--------------------------------------------------------------------------------

                       *SEE INSTRUCTION BEFORE FILLING OUT

                                  Page 6 of 11




ITEM 1(a)       NAME OF ISSUER:

                Nuvelo, Inc.

ITEM 1(b)       ADDRESS OF ISSUER'S PRINCIPAL EXECUTIVE OFFICES:

                675 Almanor Avenue
                Sunnyvale, CA 94085

ITEMS 2(a)      NAME OF PERSON FILING:

                This statement is filed by: (i) S.A.C. Capital Advisors, LLC,
                ("SAC Capital Advisors"); (ii) S.A.C. Capital Management, LLC,
                ("SAC Capital Management"); (iii) Sigma Capital Management, LLC
                ("Sigma Capital Management") with respect to Shares beneficially
                owned by Sigma Capital Associates, LLC ("Sigma Capital
                Associates"); (iv) Sigma Capital Associates with respect to
                Shares beneficially owned by it; and (v) Steven A. Cohen with
                respect to Shares beneficially owned by SAC Capital Advisors,
                SAC Capital Management, Sigma Capital Management and Sigma
                Capital Associates.

ITEM 2(b)       ADDRESS OF PRINCIPAL BUSINESS OFFICE:

                The address of the principal business office of (i) SAC Capital
                Advisors and Mr. Cohen is 72 Cummings Point Road, Stamford,
                Connecticut 06902, (ii) SAC Capital Management and Sigma Capital
                Management is 540 Madison Avenue, New York, New York 10022,
                (iii) Sigma Capital Associates is P.O. Box 58, Victoria House,
                The Valley, Anguilla, British West Indies.

ITEM 2(c)       CITIZENSHIP:

                SAC Capital Advisors, SAC Capital Management and Sigma Capital
                Management are Delaware limited liability companies. Sigma
                Capital Associates is an Anguillan limited liability company.
                Mr. Cohen is a United States citizen.

ITEM 2(d)       TITLE OF CLASS OF SECURITIES:

                Common Stock

ITEM 2(e)       CUSIP NUMBER:

                67072M103

ITEM 3          Not Applicable

                                  Page 7 of 11



ITEM 4        OWNERSHIP:

              The percentages used herein are calculated based upon the Shares
              issued and outstanding as of October 31, 2005 as reported on the
              Issuer's quarterly report on Form 10-Q filed with the Securities
              and Exchange Commission by the Issuer for the quarterly ended
              September 30, 2005.

              As of the close of business on December 30, 2005:

              1. S.A.C. Capital Advisors, LLC
              (a) Amount beneficially owned: -0-
              (b) Percent of class: 0%
              (c) (i) Sole power to vote or direct the vote: -0-
              (ii) Shared power to vote or direct the vote: -0-
              (iii) Sole power to dispose or direct the disposition: -0-
              (iv) Shared power to dispose or direct the disposition: -0-

              2. S.A.C. Capital Management, LLC
              (a) Amount beneficially owned: -0-
              (b) Percent of class: 0%
              (c) (i) Sole power to vote or direct the vote: -0-
              (ii) Shared power to vote or direct the vote: -0-
              (iii) Sole power to dispose or direct the disposition: -0-
              (iv) Shared power to dispose or direct the disposition: -0-

              3. Sigma Capital Management, LLC
              (a) Amount beneficially owned: 3,655,033
              (b) Percent of class: 8.6%
              (c) (i) Sole power to vote or direct the vote: -0-
              (ii) Shared power to vote or direct the vote: 3,655,033
              (iii) Sole power to dispose or direct the disposition: -0-
              (iv) Shared power to dispose or direct the disposition: 3,655,033

              4. Sigma Capital Associates, LLC
              (a) Amount beneficially owned: 3,655,033
              (b) Percent of class: 8.6%
              (c) (i) Sole power to vote or direct the vote: -0-
              (ii) Shared power to vote or direct the vote: 3,655,033
              (iii) Sole power to dispose or direct the disposition: -0-
              (iv) Shared power to dispose or direct the disposition: 3,655,033

              5. Steven A. Cohen
              (a) Amount beneficially owned: 3,655,033
              (b) Percent of class: 8.6%
              (c) (i) Sole power to vote or direct the vote: -0-
              (ii) Shared power to vote or direct the vote: 3,655,033
              (iii) Sole power to dispose or direct the disposition: -0-
              (iv) Shared power to dispose or direct the disposition: 3,655,033

                                  Page 8 of 11



                SAC Capital Advisors, SAC Capital Management, Sigma Capital
                Management and Mr. Cohen own directly no Shares. Pursuant to
                investment agreements, each of SAC Capital Advisors and SAC
                Capital Management share all investment and voting power with
                respect to the securities held by S.A.C. MultiQuant Fund, LLC.
                Pursuant to an investment management agreement, Sigma Capital
                Management maintains investment and voting power with respect to
                the securities held by Sigma Capital Associates. Mr. Cohen
                controls each of SAC Capital Advisors, SAC Capital Management
                and Sigma Capital. By reason of the provisions of Rule 13d-3 of
                the Securities Exchange Act of 1934, as amended, Sigma Capital
                Management and Mr. Cohen may be deemed to own beneficially
                3,655,033 Shares (constituting approximately 8.6% of the Shares
                outstanding). Each of SAC Capital Advisors, SAC Capital
                Management, Sigma Capital Management and Mr. Cohen disclaim
                beneficial ownership of any of the securities covered by this
                statement.


ITEM 5          OWNERSHIP OF FIVE PERCENT OR LESS OF A CLASS:

                If this statement is being filed to report the fact that as of
                the date hereof the reporting person has ceased to be the
                beneficial owner of more than five percent of the class of
                securities, check the following. |_|

ITEM 6          OWNERSHIP OF MORE THAN FIVE PERCENT ON BEHALF OF ANOTHER PERSON:

                Not Applicable

ITEM 7          IDENTIFICATION AND CLASSIFICATION OF THE SUBSIDIARY WHICH
                ACQUIRED THE SECURITY BEING REPORTED ON BY THE PARENT
                HOLDING COMPANY:

                Not Applicable

ITEM 8          IDENTIFICATION AND CLASSIFICATION OF MEMBERS OF THE GROUP:

                Not Applicable

                                  Page 9 of 11



ITEM 9          NOTICE OF DISSOLUTION OF GROUP:

                Not Applicable

ITEM 10         CERTIFICATION:

         By signing below the signatory certifies that, to the best of his
knowledge and belief, the securities referred to above were not acquired and are
not held for the purpose of or with the effect of changing or influencing the
control of the issuer of the securities and were not acquired and are not held
in connection with or as a participant in any transaction having that purpose or
effect.





                                  Page 10 of 11





                                    SIGNATURE

         After reasonable inquiry and to the best of my knowledge and belief, I
certify that the information set forth in this statement is true, complete and
correct.

Dated:   February 14, 2006


S.A.C. CAPITAL ADVISORS, LLC


By: /s/ Peter Nussbaum
   -----------------------------------------
Name:  Peter Nussbaum
Title: Authorized Person


S.A.C. CAPITAL MANAGEMENT, LLC


By: /s/ Peter Nussbaum
   -----------------------------------------
Name:  Peter Nussbaum
Title: Authorized Person


SIGMA CAPITAL MANAGEMENT, LLC


By: /s/ Peter Nussbaum
   -----------------------------------------
Name:  Peter Nussbaum
Title: Authorized Person


SIGMA CAPITAL ASSOCIATES, LLC


By: /s/ Peter Nussbaum
   -----------------------------------------
Name:  Peter Nussbaum
Title: Authorized Person


STEVEN A. COHEN


By: /s/ Peter Nussbaum
   -----------------------------------------
Name:  Peter Nussbaum
Title: Authorized Person


                                  Page 11 of 11