SCHEDULE 14A
                                 (Rule 14a-101)
                     INFORMATION REQUIRED IN PROXY STATEMENT
                            SCHEDULE 14A INFORMATION
                Proxy Statement pursuant to Section 14(a) of the
                         Securities Exchange Act of 1934

Filed by the Registrant |X|
Filed by a Party other than the Registrant |_|

Check the appropriate box:

|_|   Preliminary Proxy Statement
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      14a-6(e)(2))
|X|   Definitive Proxy Statement
|_|   Definitive Additional Materials
|_|   Soliciting Material Under Rule 14a-12

                             SIGA TECHNOLOGIES, INC.

                (Name of Registrant as Specified in Its Charter)


    ------------------------------------------------------------------------
    (Name of Person(s) Filing Proxy Statement, if other than the Registrant)

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                             SIGA Technologies, Inc.
                         420 Lexington Avenue, Suite 408
                            New York, New York 10170
                                 (212) 672-9100

November 17, 2006

Dear Stockholder:

      You are cordially  invited to attend the Annual Meeting of Stockholders of
SIGA  Technologies,  Inc.  which  will be held at the  offices  of Kramer  Levin
Naftalis & Frankel LLP, 1177 Avenue of the Americas,  29th Floor,  New York, New
York 10036 at 10:30 a.m. (local time) on Tuesday,  December 19, 2006, and at any
adjournment or  postponement  thereof.  On the following pages you will find the
formal notice of annual meeting and proxy statement.

      To assure that you are represented at the Annual  Meeting,  whether or not
you plan to attend the meeting in person, please read carefully the accompanying
proxy  statement,  which  describes  the  matters to be voted  upon,  and please
complete, date, sign and return the enclosed proxy card promptly.

      I hope that you will attend the  meeting and I look  forward to seeing you
there.

                                                Sincerely,


                                                /s/ Donald G. Drapkin
                                                ---------------------
                                                DONALD G. DRAPKIN
                                                Chairman of the Board



                             SIGA Technologies, Inc.
                         420 Lexington Avenue, Suite 408
                            New York, New York 10170

                    NOTICE OF ANNUAL MEETING OF STOCKHOLDERS
                         TO BE HELD ON DECEMBER 19, 2006

      NOTICE IS HEREBY  GIVEN  that the  Annual  Meeting  of  Stockholders  (the
"Annual Meeting") of SIGA Technologies,  Inc., a Delaware corporation  ("SIGA"),
will be held on Tuesday,  December 19, 2006, at 10:30 a.m.  (local time), at the
offices of Kramer  Levin  Naftalis & Frankel LLP,  1177 Avenue of the  Americas,
29th Floor, New York, New York 10036, and at any adjournment.

      At the Annual Meeting,  SIGA's stockholders will be voting on proposals to
do the following:

      1.    To elect ten directors to the Board of Directors of SIGA;

      2.    To  ratify  the  appointment  of  PricewaterhouseCoopers  LLP as the
            independent registered public accounting firm of SIGA for the fiscal
            year ending December 31, 2006; and

      3.    To  transact  such other  business as may  properly  come before the
            Annual Meeting or at any adjournment or postponement thereof.

      Stockholders  of record at the close of  business  on November 6, 2006 are
entitled to notice of, and to vote at, the Annual Meeting or any  adjournment or
postponement  thereof.  A list of such  stockholders  will be  available  at the
Annual Meeting and for any purpose related to the Annual Meeting, during the ten
days prior to the Annual Meeting,  at SIGA's office,  during  ordinary  business
hours.

      All  stockholders are cordially  invited to attend the Annual Meeting.  If
you do not expect to be present at the Annual Meeting, you are requested to fill
in,  date and sign the  enclosed  proxy  and mail it  promptly  in the  enclosed
envelope to make sure that your shares are represented at the Annual Meeting. In
the event you  decide to attend the Annual  Meeting in person,  you may,  if you
desire, revoke your proxy and vote your shares in person.

                             YOUR VOTE IS IMPORTANT

   IF YOU ARE UNABLE TO BE PRESENT PERSONALLY, PLEASE MARK, SIGN AND DATE THE
 ENCLOSED PROXY, WHICH IS BEING SOLICITED BY THE BOARD OF DIRECTORS, AND RETURN
                      IT PROMPTLY IN THE ENCLOSED ENVELOPE.

                                        By Order of the Board of Directors,


                                        /s/ Thomas N. Konatich
                                        ----------------------
                                        Thomas N. Konatich
                                        Secretary

New York, New York
November 17, 2006



                             SIGA Technologies, Inc.
                         420 Lexington Avenue, Suite 408
                            New York, New York 10170

                                 --------------
                                 PROXY STATEMENT
                         ANNUAL MEETING OF STOCKHOLDERS
                                DECEMBER 19, 2006

                                 --------------

      This proxy statement is furnished to  stockholders  of SIGA  Technologies,
Inc.   ("SIGA")  in  connection  with  the  solicitation  of  proxies,   in  the
accompanying  form, by the Board of Directors of SIGA (the "Board of Directors")
for use in voting at the Annual Meeting of Stockholders  (the "Annual  Meeting")
to be held at the offices of Kramer Levin Naftalis & Frankel LLP, 1177 Avenue of
the Americas,  29th Floor,  New York, New York 10036,  on Tuesday,  December 19,
2006, at 10:30 a.m., and at any adjournment or postponement thereof.

      This proxy statement,  and the accompanying form of proxy, are first being
mailed to stockholders on or about November 27, 2006.

                    VOTING RIGHTS AND SOLICITATION OF PROXIES

Purpose of the Annual Meeting

      The  specific  proposals  to be  considered  and acted  upon at the Annual
Meeting  are  summarized  in  the  accompanying  Notice  of  Annual  Meeting  of
Stockholders. Each proposal is described in more detail in this proxy statement.

Record Date and Outstanding Shares

      The Board of Directors has fixed the close of business on November 6, 2006
as the record date (the "Record  Date") for the  determination  of  stockholders
entitled to notice of, and to vote at, the Annual Meeting.  Only stockholders of
record at the close of  business  on the Record Date will be entitled to vote at
the Annual Meeting or any and all adjournments or postponements  thereof.  As of
the Record Date,  SIGA had issued and  outstanding  31,796,454  shares of common
stock, par value $.0001 per share ("Common Stock").

Voting at the Annual Meeting

      Each share of Common Stock outstanding on the Record Date will be entitled
to one vote on each matter submitted to a vote of the  stockholders.  Cumulative
voting by stockholders is not permitted.

      The presence,  in person or by proxy,  of the holders of a majority of the
votes  entitled  to be cast by the  stockholders  entitled to vote at the Annual
Meeting is necessary to constitute a quorum.  Abstentions and broker "non-votes"
are  counted as present  and  entitled to vote for  purposes  of  determining  a
quorum.  A  broker  "non-vote"  occurs  when  a  nominee  holding  shares  for a
beneficial owner does not vote on a particular proposal because the nominee does
not  have  discretionary  voting  power  for  that  particular  item and has not
received instructions from the beneficial owner.

      For the election of directors,  a plurality of the votes cast is required.
Abstentions  and broker  "non-votes"  are not  considered for the purpose of the
election of directors.

      For the ratification of the appointment of  PricewaterhouseCoopers  LLP as
the independent  registered  public  accounting firm of SIGA for the fiscal year
ending December 31, 2006, the affirmative  vote of a majority of the total votes
cast on such  proposal in person or by proxy at the Annual  Meeting is required.
Abstentions and broker  "non-votes" for such proposal are not considered to have
been voted on the proposal.


                                       1


Revocability and Voting of Proxies

      Any person signing a proxy in the form  accompanying  this proxy statement
has the power to revoke it prior to the Annual  Meeting or at the Annual Meeting
prior to the vote  pursuant  to the proxy.  A proxy may be revoked by any of the
following methods:

o     by writing a letter  delivered to Thomas N.  Konatich,  Secretary of SIGA,
      stating that the proxy is revoked;

o     by submitting another proxy with a later date; or

o     by attending the Annual Meeting and voting in person.

      Please note, however, that if a stockholder's shares are held of record by
a  broker,  bank or other  nominee  and that  stockholder  wishes to vote at the
Annual Meeting,  the stockholder  must bring to the Annual Meeting a letter from
the broker,  bank or other  nominee  confirming  that  stockholder's  beneficial
ownership of the shares.

      Unless we receive  specific  instructions  to the  contrary or unless such
proxy is revoked,  shares  represented  by each properly  executed proxy will be
voted:  (i) FOR the election of each of SIGA's nominees as a director;  (ii) FOR
the  ratification  of  the  appointment  of  PricewaterhouseCoopers  LLP  as the
independent registered public accounting firm of SIGA for the fiscal year ending
December 31, 2006; and (iii) with respect to any other matters that may properly
come before the Annual  Meeting,  at the discretion of the proxy  holders.  SIGA
does not  presently  anticipate  that any other  business  will be presented for
action at the Annual Meeting.

Solicitation

      SIGA will pay the costs relating to this proxy  statement,  the proxy card
and the Annual  Meeting.  SIGA may reimburse  brokerage  firms and other persons
representing  beneficial  owners of  shares  for their  expenses  in  forwarding
solicitation  material to  beneficial  owners.  Directors,  officers and regular
employees may also solicit proxies by telephone,  facsimile or other means or in
person. They will not receive any additional payments for the solicitation.


                                       2


                                 PROPOSAL NO. 1

                              ELECTION OF DIRECTORS

      Ten directors are to be elected at the Annual Meeting to hold office until
the next Annual Meeting of  Stockholders  and until their  successors  have been
duly elected and qualified.  Unless otherwise instructed, the proxy holders will
vote the proxies  received by them FOR the election of the ten persons  named in
the table  below as  directors  of SIGA.  Proxies  cannot be voted for a greater
number of persons  than the nominees  named.  In the event that any of the below
listed  nominees for director  should  become  unavailable  for election for any
presently  unforeseen  reason,  the persons named in the accompanying proxy form
have the right to use their discretion to vote for a substitute.

      THE BOARD OF DIRECTORS  RECOMMENDS  THAT THE  STOCKHOLDERS  VOTE "FOR" THE
ELECTION  (ITEM 1 OF THE ENCLOSED  PROXY CARD) OF MR.  DRAPKIN,  MR. ANTAL,  MR.
CONSTANCE,  DR. MJALLI,  DR. OZ, DR. ROSE, MR. SAVAS, MS. SLOTKIN AND DR. WEINER
AS DIRECTORS.

Director Nominee Information

The  following  table  sets  forth  biographical  information  of each  director
nominee,  including their ages, data on their business backgrounds and the names
of public  companies  and other  selected  entities for which they also serve as
directors:

         Name                                   Age      Position
         ----                                   ---      --------
         Donald G. Drapkin*                     58       Chairman of the Board
         James J. Antal*                        55       Director
         Thomas E. Constance*                   69       Director
         Adnan M. Mjalli, Ph.D.                 42       Director
         Mehmet C. Oz, M.D. *                   44       Director
         Eric A. Rose, M.D. *                   54       Director
         Paul G. Savas*                         43       Director
         Judy S. Slotkin*                       53       Director
         Michael A.  Weiner, M.D. *             60       Director
         Scott M. Hammer, M.D. *                59       Director

      *     Determined by the Board of Directors to be  independent  pursuant to
            Rule 4200 of the NASD Marketplace Rules.

      Donald G.  Drapkin  has served as  Chairman of the Board and a director of
SIGA since April 19, 2001.  Mr. Drapkin has been Vice Chairman and a director of
MacAndrews  & Forbes  Holdings  Inc. and various of its  affiliates  since 1987.
Prior to joining  MacAndrews & Forbes, Mr. Drapkin was a partner in the law firm
of  Skadden,  Arps,  Slate,  Meagher & Flom LLP for more than  five  years.  Mr.
Drapkin is also a director  of the  following  corporations  which file  reports
pursuant to the  Securities  Exchange  Act of 1934:  Anthracite  Capital,  Inc.,
Playboy Enterprises, Inc., Revlon Consumer Products Corporation, Revlon Inc. and
Nephros,  Inc. Mr. Drapkin is also a director of PharmaCore,  Inc. and TransTech
Pharma, Inc.

      James J. Antal has served as a director of SIGA since  November  2004. Mr.
Antal has been an active  consultant and founding  investor in several  Southern
California based emerging  companies since his retirement from Experian in 2002.
He has served as Chief  Financial  Advisor  to Black  Mountain  Gold  Coffee Co.
(2003-2005),  and as Chief  Financial  Officer of Pathway  Data,  Inc.  (2005 to
present).  Mr. Antal joined the Board of Directors and serves as the Chairman of
the audit committee for  ClevelandBioLabs,  effective upon the completion of the
CBLI IPO,  which  occurred  in July,  2006.  Mr.  Antal was the Chief  Financial
Officer and Chief  Investment  Officer  from 1996 to 2002 for  Experian,  a $1.6
billion global information services subsidiary of UK-based GUS plc. Prior to the
GUS  acquisition  of  Experian  (the  former TRW Inc.  Information  Systems  and
Services  businesses),  Mr. Antal held various  finance  positions with TRW from
1978 to 1996, including Senior VP of Finance for TRW Information


                                       3


Systems and Services and TRW Inc. Corporate Director of Financial  Reporting and
Accounting. He earned his undergraduate degree in accounting from The Ohio State
University in 1973, and became a certified public  accountant (Ohio) in 1974. He
engaged in active practice as a CPA with Ernst & Ernst until 1978. Mr. Antal has
served as a director of First American Real Estate Solutions,  an Experian joint
venture with First American Financial Corp.

      Thomas E. Constance has served as a director of SIGA since April 19, 2001.
Mr.  Constance is Chairman and, since 1994, a partner of Kramer Levin Naftalis &
Frankel LLP, a law firm in New York City. Mr.  Constance  serves as a Trustee of
the M.D.  Sass  Foundation  and St.  Vincent's  Services.  He also serves on the
Advisory Board of Directors of Barington Capital, L.P.

      Adnan M.  Mjalli,  Ph.D.  has served as a director  of SIGA since  January
2004. Dr. Mjalli founded TransTech Pharma, Inc., a privately held drug discovery
company  in High  Point,  North  Carolina,  in 1999 and has since  served as its
President and Chief Executive  Officer.  He also serves as Chairman of the Board
of  PharmaCore,  Inc.  where he  previously  served  as  President  and CEO from
December of 1998 to November  2000.  Dr. Mjalli  obtained his Ph.D. in medicinal
chemistry in 1989 from the University of Exeter,  UK. His postdoctoral  work was
carried out at the University of Rochester.  Prior to founding TransTech Pharma,
he held various  positions of increasing  responsibility  in research and senior
management at several  pharmaceutical  and  biotechnology  companies,  including
Merck & Co., Inc.

      Mehmet C. Oz, M.D.  has served as a director of SIGA since April 19, 2001.
Dr. Oz has been a Cardiac Surgeon at Columbia University  Presbyterian  Hospital
since 1993 and a  Professor  of Surgery  and Vice  Chairman  for  Cardiovascular
Services of the  Department of Surgery there since July 2001. Dr. Oz directs the
following  programs  at New  York  University  Presbyterian  Hospital,  Columbia
University:  the Cardiovascular  Institute,  the complementary medicine program,
the clinical  profusion program and clinical trials of new surgical  technology.
Dr. Oz received his undergraduate  degree from Harvard  University in 1982, and,
in  1986,  he  received  a joint  M.D./M.B.A.  degree  from  the  University  of
Pennsylvania Medical School and the Wharton School of Business.

      Eric A. Rose,  M.D. has served as a director of SIGA since April 19, 2001.
From April 19,  2001 until  June 21,  2001,  Dr.  Rose  served as Interim  Chief
Executive  Officer of SIGA. Dr. Rose is currently  Chairman of the Department of
Surgery and  Surgeon-in-Chief  of the Columbia  Presbyterian  Center of New York
Presbyterian  Hospital,  a position he has held since August 1994. Dr. Rose is a
past President of the International  Society for Heart and Lung Transplantation.
Dr. Rose was recently  appointed as Morris & Rose Milstein  Professor of Surgery
at Columbia  University's  College of  Physicians  and  Surgeons'  Department of
Surgery. Dr. Rose is a director of PharmaCore,  Inc., TransTech Pharma, Inc. and
a former  director of Nexell  Therapeutics  Inc.  (f/k/a  VimRx).  Dr. Rose is a
graduate of both Columbia College and Columbia  University College of Physicians
& Surgeons.

      Paul G. Savas has served as a director  of SIGA since  January  2004.  Mr.
Savas has been an Executive  Vice  President  of Finance at  MacAndrews & Forbes
Holdings,  Inc. and its  affiliates  since May 2006.  Prior to that he served in
various positions at MacAndrews & Forbes and its affiliates, including as Senior
Vice President of Finance from October 2002 until May 2006,  Vice President from
1998 until 2002,  and  Director of Corporate  Finance from 1994 until 1998.  Mr.
Savas is a director  of Rev  Holdings  LLC,  Clarke  American  Corp.,  TransTech
Pharma, Inc. and PharmaCore, Inc.

      Judy S. Slotkin has served as a director of SIGA since  November 2004. Ms.
Slotkin was Co-Head of the Finance  Committee of the Modern  Africa Fund, a $120
million  private  equity fund,  from 1998 until 2003.  Ms.  Slotkin was formerly
Department  Head  in the  Corporate  Finance  Division  of  Citigroup  (Citibank
Investment Bank) where she was responsible for various  businesses and the first
head of the group's  Capital  Markets  Desk.  Prior to that,  Ms.  Slotkin  held
various positions in the Citigroup (Citibank)  commercial bank. Ms. Slotkin is a
director of Nephros,  Inc.  Ms.  Slotkin  received her  undergraduate  degree in
accounting from Fairleigh Dickinson  University in 1976 and in 1980 she received
her MBA in Finance from Fordham University.

      Michael A.  Weiner,  M.D. has served as a director of SIGA since April 19,
2001. Dr. Weiner is the Hettinger Professor of Pediatrics at Columbia University
College of Physicians  and Surgeons  since 1996. Dr. Weiner is also the Director
of  Pediatric  Oncology  at New York  Presbyterian  Hospital.  Dr.  Weiner was a
director of Nexell Therapeutics,  Inc. (f/k/a VimRx) from March 1996 to February
1999. Dr. Weiner is a 1972


                                       4


graduate of the New York State Health Sciences Center at Syracuse and was a post
graduate student at New York University and Johns Hopkins University.

      Dr.  Hammer is the  Harold C. Neu  Professor  of  Medicine,  Professor  of
Epidemiology  and Chief of the Division of  Infectious  Diseases at the Columbia
University  Medical  Center  (CUMC),  a  position  he has held since  1999.  Dr.
Hammer's  major  investigative  interest is the treatment and  prevention of HIV
disease.  He is an investigator in the National  Institutes of Health  sponsored
AIDS Clinical  Trials Group (ACTG),  a multicenter  organization  which performs
clinical  trials  designed to improve the  understanding  and  treatment  of HIV
infection and its complications. As an ACTG investigator, Dr. Hammer chaired the
two largest national trials of antiretroviral  therapy carried out by that group
in the 1990's,  studies which contributed to the current standard of care of HIV
infection.  In  addition  to his  interest  in the  treatment  of  persons  with
established  HIV  infection,  Dr.  Hammer  is an  investigator  in the  National
Institutes of Health  sponsored HIV Vaccine Trials Network (HVTN), a multicenter
organization whose mission is to develop an effective preventive HIV vaccine. He
is Chair of the AIDS Vaccine  Research  Working Group, an advisory  committee to
the  Division of AIDS,  NIAID.  He is a former Chair of the  Antiviral  Products
Advisory  Committee of the Food and Drug  Administration and currently serves on
the Editorial Board of the New England Journal of Medicine.  Dr. Hammer is Chair
of the International  AIDS Society-USA's  Antiretroviral  Guidelines Panel, is a
member of the Governing Council of the International  AIDS Society,  is a member
of the World Health  Organization's  Strategic and Technical  Advisory Committee
for HIV/AIDS,  serves as Co-Chair of the Steering  Committee of the WHO's Global
HIV  Drug  Resistance  Surveillance  Program,  and  continues  in  his  role  as
Guidelines  Development Group Chair of the WHO's  Antiretroviral  Guidelines for
Resource  Limited  Settings.  He has  served  as a member  of the  International
Advisory  Committees  of  the  Swiss  HIV  Cohort  Study,  the  French  National
Association  for AIDS Research and the HIV-NAT  (Netherlands-Australia-Thailand)
Collaborative  Research  Network.  In his  role  as  Chief  of the  Division  of
Infectious Diseases at CUMC, he is dedicated to fellow and faculty growth and to
the development of state-of-the-art  infection surveillance at the institutional
and regional levels to improve and protect the public health.

Meetings of the Board of Directors

      The Board of Directors of SIGA held six meetings during 2005. During 2005,
one  director  attended  fewer than 75% of the  aggregate of the meetings of the
Board of Directors  and  committees  thereof,  upon which such  director  served
during  the  period for which he has been a director  or  committee  member.  In
addition,  2 actions were taken during 2005 by unanimous  written consent of the
directors.

      Those members of the Board of Directors who are  independent as defined by
Rule 4200 of the NASD Marketplace Rules (the  "Independent  Directors") are also
required,  pursuant  to  Rule  4350(c)(2)  of the  NASD  Marketplace  Rules,  to
regularly convene executive  sessions where only such Independent  Directors are
present. Such meetings may be in conjunction with  regularly-scheduled  meetings
of the  Board of  Directors.  Each  member  of the  Board of  Directors  is also
expected to attend the annual meeting of stockholders of SIGA.  Seven members of
the Board of Directors attended SIGA's 2005 annual meeting of stockholders.

Committees of the Board of Directors

      The Board of  Directors  currently  has,  and  appoints  the  members  of,
standing Audit, Compensation and Nominating and Corporate Governance Committees.
Each member of the Audit,  Compensation and Nominating and Corporate  Governance
Committees is an Independent  Director.  Each of these  committees has a written
charter  approved by the Board of the  Directors  in March 2004.  A copy of each
charter  is  posted on  SIGA's  website  at  www.siga.com  under the  "Corporate
Governance" section.

      Audit  Committee.  The  Audit  Committee,   which  currently  consists  of
directors Paul G. Savas,  Judy S. Slotkin and James J. Antal,  held ten meetings
during 2005. The Board of Directors has  determined  that each of the members of
the Audit  Committee  is  "independent"  under the  applicable  laws,  rules and
regulations.  The Company has determined  that Mr. Savas is an "Audit  Committee
financial  expert"  within the  meaning of  Regulation  S-K  promulgated  by the
Securities  and  Exchange  Commission  (the  "SEC").  The  purpose  of the Audit
Committee is to assist the Board of Directors in the  oversight of the integrity
of the financial statements of SIGA, SIGA's compliance with legal and regulatory
matters, the independent registered public accounting firm's qualifications and


                                       5


independence,  and the  performance  of  SIGA's  independent  registered  public
accounting  firm. The primary  responsibilities  of the Audit  Committee are set
forth in its charter,  and include various matters with respect to the oversight
of SIGA's accounting and financial reporting process and audits of the financial
statements of SIGA on behalf of the Board of Directors. The Audit Committee also
selects the independent  registered public accounting firm to conduct the annual
audit of the financial  statements of SIGA;  reviews the proposed  scope of such
audit;  reviews  accounting and financial  controls of SIGA with the independent
registered  public  accounting  firm and our  financial  accounting  staff;  and
reviews and approves  transactions between us and our directors,  officers,  and
their  affiliates.  A copy of the Audit Committee charter is available on SIGA's
website (as described above). Also see "Audit Committee Report."

      Compensation  Committee.  The  Compensation  Committee,   which  currently
consists of directors  Donald G.  Drapkin,  Paul G. Savas and Mehmet C. Oz, held
one meeting during 2005. The Board of Directors has determined  that each of the
members of the Compensation Committee is "independent" within the meaning of the
NASDAQ listing standards. The Compensation Committee functions include reviewing
and  approving  the  compensation  and benefits for SIGA's  executive  officers,
administering  SIGA's  stock  plans and making  recommendations  to the Board of
Directors regarding these matters. A copy of the Compensation  Committee charter
is available on SIGA's website. Also see "Compensation Committee Report."

      Nominating  and  Corporate  Governance   Committee.   The  Nominating  and
Corporate  Governance  Committee (the "Nominating  Committee"),  which currently
consists of directors Judy S. Slotkin, James J. Antal and Michael A. Weiner, was
formed in March 2004 and held three meetings in 2005. The Board of Directors has
determined that each of the members of the Nominating Committee is "independent"
within the meaning of the NASDAQ listing standards.  The Nominating Committee is
responsible  for  searching  for and  recommending  to the  Board  of  Directors
potential nominees for director positions,  making  recommendations to the Board
of Directors  regarding the size and  composition  of the Board of Directors and
its committees,  monitoring the Board of Director's effectiveness and developing
and implementing SIGA's corporate governance  procedures and policies. A copy of
the Nominating and Corporate Governance Committee charter is available on SIGA's
website.

      In  selecting  candidates  for the  Board  of  Directors,  the  Nominating
Committee  begins by  determining  whether the incumbent  directors  whose terms
expire at the  annual  meeting  of  stockholders  desire  and are  qualified  to
continue  their service on the Board of Directors.  SIGA is of the view that the
continuing service of qualified  incumbents promotes stability and continuity in
the board  room,  giving SIGA the benefit of the  familiarity  and insight  into
SIGA's affairs that its directors have  accumulated  during their tenure,  while
contributing  to the Board of Director's  ability to work as a collective  body.
Accordingly,  it is the  policy  of the  Nominating  Committee,  absent  special
circumstances, to nominate qualified incumbent directors who continue to satisfy
the  Nominating  Committee's  criteria for membership on the Board of Directors,
whom  the  Nominating   Committee  believes  will  continue  to  make  important
contributions to the Board of Directors and who consent to stand for re-election
and, if  re-elected,  to continue  their service on the Board of  Directors.  If
there are positions on the Board of Directors for which the Nominating Committee
will not be re-nominating an incumbent director, or if there is a vacancy on the
Board of Directors,  the Nominating  Committee will solicit  recommendations for
nominees from persons whom the  Nominating  Committee  believes are likely to be
familiar with qualified candidates,  including members of the Board of Directors
and management of SIGA. The Nominating  Committee may also engage a professional
search firm to assist in the identification of qualified candidates, but did not
do so in 2005. As to each  recommended  candidate that the Nominating  Committee
believes merits serious consideration,  the Nominating Committee will collect as
much  information,  including  without  limitation,  soliciting views from other
directors  and SIGA's  management  and having one or more  Nominating  Committee
members  interview  each such  candidate,  regarding  each candidate as it deems
necessary or appropriate  in order to make an informed  decision with respect to
such candidate.  Based on all available information and relevant considerations,
the Nominating  Committee will select,  for each  directorship  to be filled,  a
candidate  who,  in the view of the  Nominating  Committee,  is most  suited for
membership  on the  Board of  Directors.  In  making  its  selection,  SIGA will
evaluate  candidates  proposed by  stockholders  under  criteria  similar to the
evaluation  of other  candidates,  except  that  the  Nominating  Committee  may
consider,  as one of the factors in its  evaluation of  stockholder  recommended
nominees, the size and duration of the interest of the recommending  stockholder
or stockholder group in the equity of SIGA. This  consideration may also include
how long the  recommending  stockholder  intends to continue  holding its equity
interest in SIGA.


                                       6


      The  Nominating  Committee has adopted a policy with regard to the minimum
qualifications  that must be met by a Nomination  Committee-recommended  nominee
for a position on SIGA's Board of  Directors,  which policy is described in this
paragraph.  The Nominating  Committee generally requires that all candidates for
the Board of Directors be of high personal integrity and ethical character.  The
Nominating Committee requires that candidates not have any interests that would,
in the view of the Nominating Committee, materially impair his or her ability to
(i) exercise  independent  judgment or (ii)  otherwise  discharge  the fiduciary
duties owed as a director to SIGA and its stockholders.  In addition, candidates
must be able to represent  fairly and equally all  stockholders  of SIGA without
favoring or advancing any particular  stockholder or other constituency of SIGA.
Candidates must have demonstrated achievement in one or more fields of business,
professional,   governmental,  communal,  scientific  or  educational  endeavor.
Candidates  are  expected  to have  sound  judgment  and a general  appreciation
regarding major issues facing public  companies of a size and operational  scope
similar  to  SIGA,  including  contemporary   governance  concerns,   regulatory
obligations of a public issuer,  strategic business  planning,  competition in a
global economy,  and basic concepts of corporate  finance.  Candidates must also
have, and be prepared to devote,  adequate time to the Board and its committees.
It is expected that,  taking into account their other business and  professional
commitments,  including  their  service on the boards of other  companies,  each
candidate  will be available to attend  meetings of the Board and any committees
on  which  the  candidate  will  serve,  as well as  SIGA's  annual  meeting  of
stockholders.  SIGA also  requires  that at least a  majority  of the  directors
serving at any time on the Board are independent,  as defined under the rules of
the NASDAQ  stock  market and that at least three of the  directors  satisfy the
financial  literacy  requirements  required  for service on the Audit  Committee
under the rules of the NASDAQ stock market.

      The  Nominating  Committee  has  adopted  a  policy  with  regard  to  the
consideration of director candidates  recommended by stockholders,  the material
elements  of which  policy  are  described  in this  paragraph.  The  Nominating
Committee will consider recommendations for nomination for director submitted by
holders  of  SIGA's  shares  entitled  to  vote  generally  in the  election  of
directors.   The  Nominating   Committee  will  give   consideration   to  these
recommendations  for positions on the Board where the  Nominating  Committee has
not  determined  to  re-nominate  a  qualified  incumbent  director.  While  the
Nominating  Committee  has not  established  a minimum  number of shares  that a
stockholder  must  own in order  to  present  a  nominating  recommendation  for
consideration, or a minimum length of time during which the stockholder must own
its shares, the Nominating Committee may take into account the size and duration
of a  recommending  stockholder's  ownership  interest in SIGA.  The  Nominating
Committee  may also  consider  whether  the  stockholder  making the  nominating
recommendation   intends  to   maintain  an   ownership   interest  in  SIGA  of
substantially  the  same  size as at its  interest  at the  time of  making  the
recommendation.  The Nominating Committee may refuse to consider recommendations
of nominees  who do not satisfy the  minimum  qualifications  prescribed  by the
Nominating Committee for board candidates.

      The  Nominating  Committee  has  adopted  procedures  to  be  followed  by
stockholders  in  submitting  recommendations  of candidates  for director.  The
procedures  are posted on SIGA's  website at  www.siga.com  under the "Corporate
Governance" section, and described in this paragraph. A stockholder (or group of
stockholders)  wishing  to  submit a  nominating  recommendation  for an  annual
meeting of  stockholders  should try to ensure that it is  received by SIGA,  as
provided herein, not later than 120 calendar days prior to the first anniversary
of the date of the proxy statement for the prior annual meeting of stockholders.
All stockholder nominating  recommendations  should be in writing,  addressed to
"the  Nominating  and  Corporate  Governance  Committee"  care of  SIGA's  Chief
Financial Officer at SIGA's principal headquarters,  420 Lexington Avenue, Suite
408, New York, New York 10170.  Submissions  should be made by mail,  courier or
personal  delivery.  A nominating  recommendation  should be  accompanied by the
following information concerning each recommending stockholder:

o     The name and address,  including  telephone  number,  of the  recommending
      stockholder;

o     The number and class of SIGA's shares owned (beneficially or of record) by
      the  recommending  stockholder  and the time  period for which such shares
      have been held;

o     A statement from the  stockholder as to whether the stockholder has a good
      faith  intention to continue to hold the reported  shares through the date
      of SIGA's next annual meeting of stockholders;

o     Sufficient  information  about the  proposed  nominee  for the  Nominating
      Committee to make an informed decision regarding the qualifications of the
      proposed nominee;


                                       7


o     Any  relationship  between  the  proposed  nominee  and  the  recommending
      stockholder; and

o     Such other information as the Nominating Committee may reasonably request.

The nominating recommendation must be accompanied by the consent of the proposed
nominee  to be  interviewed  by the  Nominating  Committee,  if  the  Nominating
Committee  chooses to do so in its discretion (and the recommending  stockholder
must  furnish the  nominee's  contact  information  for this  purpose),  and, if
nominated and elected, to serve as a director of SIGA.

Compensation Committee Interlocks and Insider Participation

      None.

Code of Ethics

      SIGA has adopted a code of ethics and business conduct that applies to its
officers,  directors and  employees,  including  without  limitation,  our Chief
Executive  Officer,  Chief Financial Officer and Chief Scientific  Officer.  The
Code  of  Ethics  and  Business  Conduct  is  available  on  SIGA's  website  at
www.siga.com under the "Corporate Governance" section.

Stockholder Communications with the Board of Directors

      SIGA  stockholders may send  communications to the Board, any committee of
the Board or an individual director.  The process for so communicating is posted
on SIGA's website at www.siga.com under the "Corporate Governance" section.


                                       8


                          REPORT OF THE AUDIT COMMITTEE

      The members of the Audit  Committee  have been  appointed  by the Board of
Directors.  During the 2005 fiscal year, the Audit Committee consisted solely of
independent  directors,  as defined in Rule  4200(a)(15) of the NASD Marketplace
Rules. The Audit Committee operates under a written charter that was amended and
restated by the Board of  Directors  in March 2004 in order to assure  continued
compliance by SIGA with SEC and NASDAQ rules enacted in response to requirements
of the Sarbanes-Oxley Act.

      The Audit  Committee  assists the Board of  Directors  in  monitoring  the
integrity of SIGA's  financial  statements,  the independent  registered  public
accounting  firm's  qualifications  and  independence,  the  performance  of the
independent  registered  public accounting firm, and the compliance by SIGA with
legal and regulatory requirements. Management is responsible for SIGA's internal
controls and the financial reporting process. The independent  registered public
accounting  firm is responsible  for  performing an independent  audit of SIGA's
financial  statements in accordance with generally  accepted auditing  standards
and for  issuing a report on those  financial  statements.  The Audit  Committee
monitors and oversees these processes.

      In this  context,  the Audit  Committee  has  reviewed and  discussed  the
audited  financial  statements  for  the  year  ended  December  31,  2005  with
management and with  PricewaterhouseCoopers  LLP, SIGA's independent  registered
public    accounting    firm.   The   Audit   Committee   has   discussed   with
PricewaterhouseCoopers  LLP the matters required to be discussed by Statement on
Auditing  Standards  No.  61  (Communications  with  Audit  Committees),   which
includes,  among  other  items,  matters  related to the conduct of the audit of
SIGA's annual financial statements.

      The Audit  Committee  has also  received the written  disclosures  and the
letter from  PricewaterhouseCoopers LLP required by Independence Standards Board
Standard  No.  1  (Independence  Discussions  with  Audit  Committees)  and  has
discussed with  PricewaterhouseCoopers  LLP the issue of their independence from
SIGA and management. In addition, the Audit Committee has considered whether the
provision of non-audit services by the independent  registered public accounting
firm in 2005 is compatible with  maintaining the auditors'  independence and has
concluded that it is.

      Based on its review of the audited  financial  statements  and the various
discussions  noted  above,  the  Audit  Committee  recommended  to the  Board of
Directors  that the audited  financial  statements  be included in SIGA's Annual
Report on Form 10-K for the year ended  December 31, 2005.  The Audit  Committee
has also  recommended,  subject to  stockholder  ratification,  the selection of
SIGA's  independent  registered  public  accounting  firm  for the  year  ending
December 31, 2006.

      The members of the Audit Committee are Paul G. Savas,  Judy S. Slotkin and
James J.  Antal,  none of whom is or,  during the  fiscal  year  2005,  was,  an
employee of SIGA.

                              Respectfully submitted by the Audit Committee,
                              Paul G. Savas, Chairman
                              James J. Antal
                              Judy S. Slotkin


                                       9


             COMPENSATION COMMITTEE REPORT ON EXECUTIVE COMPENSATION

      During the year ended  December 31, 2005, the  Compensation  Committee was
comprised of Donald G. Drapkin, Paul G. Savas and Mehmet C. Oz. The Compensation
Committee's  duties  include  determination  of the Company's  compensation  and
benefit  policies  and  practices  for  executive  officers  and key  managerial
employees.  In  accordance  with rules  established  by the SEC,  the Company is
required to provide certain data and  information in regard to the  compensation
provided to the Company's Chief Executive Officer and the four other most highly
compensated executive officers.

      Compensation Policies

      The  overall  objectives  of the  Company's  compensation  program  are to
attract  and  retain the best  possible  executive  talent,  to  motivate  these
executives to achieve the goals inherent in the Company's business strategy,  to
maximize the link between  executive and stockholder  interests  through a stock
option  plan  and to  recognize  individual  contributions  as well  as  overall
business  results.  To achieve  these  objectives,  the Company has developed an
overall  compensation  strategy  and  specific  compensation  plans  that  tie a
substantial portion of an executive's compensation to performance.

      The key elements of the Company's  compensation  program  consist of fixed
compensation  in the form of base salary,  and the  discretion to award variable
compensation  in the forms of annual  incentive  compensation  and stock  option
awards.  The  Compensation  Committee's  policies  with respect to each of these
elements are discussed  below.  In addition,  while the elements of compensation
described below are considered separately, the Compensation Committee takes into
account the full compensation package afforded by the Company to the individual,
including  pension  benefits,  insurance  and  other  benefits,  as  well as the
programs described below.

      Base Salaries

      Base  salaries  for  executive  officers  are  determined  based  upon the
Compensation Committee's evaluation of the responsibilities of the position held
and the experience of the individual,  and by reference to historical  levels of
salary paid by the Company.

      Salary  adjustments are based on a periodic  evaluation of the performance
of the Company and each executive  officer,  as well as financial results of the
business.  The  Compensation  Committee  takes  into  account  the effect of any
corporate  transactions that have been consummated during the relevant year and,
where appropriate,  also considers  non-financial  performance  measures.  These
include the Company's market share,  scientific developments and improvements in
relations with employees.

      Annual Incentive Compensation Awards

      Annual   incentive   compensation  is  payable   pursuant  to  contractual
provisions  with  certain  executives  which  provide   eligibility  to  receive
performance  based bonuses and/or  discretionary  bonuses.  The annual incentive
compensation earned by the executives with respect to 2005 was discretionary and
determined by the Compensation Committee.

      Other Incentive Compensation Awards

      The principal component of executive compensation is the granting of stock
options,  which are  intended as a tool to  attract,  provide  incentive  to and
retain those executives who make the greatest contribution to the business,  and
who can have the greatest effect on the Company's long-term  profitability.  The
exercise  price of stock  options is set at a price equal to the market price of
the Common Stock at the time of the grant. The options therefore do not have any
value to the executive unless the market price of the Common Stock rises.

      Chief Executive Officer Compensation

      Dr.  Kasten began service as Chief  Executive  Officer on July 2, 2004 and
resigned his position  effective April 30, 2006. The  compensation of Dr. Kasten
had been governed by the terms of his Employment  Agreement  dated as of July 2,
2004,  which terms were modified as of his  resignation,  all as described below
under the heading "Employment Contracts."


                                       10


      Tax Deductibility Of Executive Compensation

      The  Compensation  Committee  attempts  to ensure  full  deductibility  of
compensation  notwithstanding  the  limitation on the  deductibility  of certain
compensation  in excess  of one  million  dollars  under  Section  162(m) of the
Internal  Revenue Code of 1986,  as amended (the "Code").  The  Company's  stock
options  are  designed so as to cause stock  options and bonuses  granted  there
under to be exempt from the limitations contained in Section 162(m) of the Code.

                         Respectfully submitted by the Compensation Committee,
                         Donald G. Drapkin
                         Paul G. Savas
                         Mehmet C. Oz


                                       11


                            COMMON STOCK PERFORMANCE

      The following line graph compares the cumulative total stockholder  return
through December 31, 2005,  assuming  reinvestment of dividends,  by an investor
who invested $100 on December 31, 2000 in each of (i) the Common Stock, (ii) the
NASDAQ National Market-US; and (iii) the NASDAQ Pharmaceutical Index.

                              [LINE CHART OMITTED]



Value of Initial Investment         12/31/00    12/31/01    12/31/02    12/31/03    12/31/04    12/31/05
--------------------------------   ----------  ----------  ----------  ----------  ----------  ----------
                                                                              
SIGA Technologies, Inc.             $ 100.00    $  91.77    $  45.25    $  72.47    $  52.53    $  30.06
NASDAQ Composite Index              $ 100.00    $  83.80    $  45.81    $  66.77    $  70.86    $  72.87
NASDAQ Biotech Composite Index      $ 100.00    $  78.95    $  54.06    $  81.09    $  88.06    $  89.27



                                       12


                                   MANAGEMENT

Officers

      The  following  table sets forth certain  information  with respect to the
executive officers of SIGA:



      Name                                 Age    Position
      ----                                 ---    --------
                                            
      Bernard L. Kasten Jr. M.D. (1)       60     Director, Chief Executive Officer
      Thomas N. Konatich (2)               60     Vice President, Chief Financial Officer, Secretary and Treasurer
      Dennis E. Hruby, Ph.D.               54     Vice President, Chief Scientific Officer
      John R. Odden (3)                    52     Vice President - Business Development


      (1)   Dr.  Kasten became Chief  Executive  Officer in the third quarter of
            2004.  Dr.  Kasten  resigned  as  Chief  Executive  Officer  of SIGA
            effective as of April 30, 2006.

      (2)   Mr.  Konatich was  appointed to serve in an  additional  capacity as
            Acting Chief Executive Officer effective as of May 1, 2006.

      (3)   Mr. Odden became Vice President -- Business Development in the third
            quarter of 2004. He resigned as Vice President Business  Development
            in September, 2005.

      Bernard L.  Kasten,  Jr.,  M.D.  has been a director of SIGA since May 23,
2003 and was Chief  Executive  Officer  from the third  quarter of 2004  through
April 30,  2006.  Prior to becoming  Chief  Executive  Officer of SIGA and since
February 2002, Dr. Kasten has been Vice  President,  Medical  Affairs of medPlus
Inc., a healthcare information technology company and a wholly-owned  subsidiary
of Quest  Diagnostics,  Inc., a  diagnostic  testing,  information  and services
company.  Since 1975,  Dr.  Kasten has been a Diplomat of the American  Board of
Pathology with a sub-specialty  certification 1976 in Medical Microbiology.  Dr.
Kasten's staff  appointments have included service in the Division of Laboratory
Services at The Cleveland Clinic; Associate of Pathology and Laboratory Services
at the  Bethesda  Hospital  Systems  in  Cincinnati,  Ohio and Chief  Laboratory
Officer at Quest  Diagnostics  Incorporated.  Dr. Kasten was a founder of Plexus
Vaccine Inc., a vaccine company of which SIGA acquired  substantially all of the
assets in May 2003.  Dr.  Kasten is also a director of Seracare  Life  Sciences,
Inc. Dr. Kasten is an author of "Infectious Disease Handbook" 5th Edition, 2003,
Lexi-Comp Inc.

      Thomas N. Konatich has served as Vice President,  Chief Financial  Officer
and Treasurer  since April 1, 1998.  He was named  Secretary of SIGA on June 29,
2001 and from October 5, 2001 until July 2, 2004 was our Acting Chief  Executive
Officer.  Mr. Konatich resumed the position of Acting Chief Executive Officer on
May 1, 2006. From November 1996 through March 1998, Mr. Konatich served as Chief
Financial  Officer  and  a  director  of  Innapharma,  Inc.,  a  privately  held
pharmaceutical  development  company.  From  1993  through  November  1996,  Mr.
Konatich served as Vice President and Chief Financial Officer of Seragen,  Inc.,
a publicly traded biopharmaceutical development company. Mr. Konatich has an MBA
from the Columbia Graduate School of Business.

      Dennis E. Hruby,  Ph.D.  has served as Vice  President - Chief  Scientific
Officer since June 2000. From April 1, 1997 through June 2000, Dr. Hruby was our
Vice  President of Research.  From  January 1996 through  March 1997,  Dr. Hruby
served as a senior  scientific  advisor to SIGA.  Dr.  Hruby is a  Professor  of
Microbiology at Oregon State  University,  and from 1990 to 1993 was Director of
the Molecular and Cellular Biology Program and Associate  Director of the Center
for Gene Research and Biotechnology.  Dr. Hruby specializes in virology and cell
biology  research,  and  the use of  viral  and  bacterial  vectors  to  produce
recombinant  vaccines.  He is a member of the American Society of Virology,  the
American  Society  for  Microbiology  and a fellow of the  American  Academy  of
Microbiology.  Dr. Hruby received a Ph.D. in microbiology from the University of
Colorado Medical Center and a B.S. in microbiology from Oregon State University.

      John R. Odden had served as Vice President -- Business Development of SIGA
from the third quarter of 2004 until September, 2005. From October 2002 until he
became Vice  President -- Business  Development  of SIGA in the third quarter of
2004, he was Vice President,  Business  Development for Quest Diagnostics,  Inc.
and its MedPlus,  Inc.  division,  the nation's  leading provider of diagnostics
testing,  information  and services,  where he was  responsible  for launching a
national   biosurveillance   solution   for   homeland   security  and  managing
relationships with


                                       13


major healthcare  information  technology  companies.  From 1996 through October
2002,  he held a series  of  progressive  leadership  roles at First  Consulting
Group,  a leading  provider of consulting and systems  integration  services for
life sciences,  healthcare and government health services businesses.  Mr. Odden
has a B.S. in mathematics from the California Institute of Technology.

Summary Compensation Table

      The following table sets forth the total  compensation paid or accrued for
the years ended  December 31, 2005,  2004 and 2003, for each person who acted as
SIGA's Chief  Executive  Officer at any time during the year ended  December 31,
2005, and its most highly compensated  executive officers,  other than its Chief
Executive Officer, whose salary and bonus for the fiscal year ended December 31,
2005 were in excess of $100,000 each.

                           Summary Compensation Table



                                                                                                           Long-Term
                                                                                                         Compensation
                                                                                                          Securities
                                                                         Other Annual                     Underlying
Name and Principal Position                   Year       Salary ($)     Comensation ($)    Bonus ($)      Options (#)
---------------------------                 -------     ------------   -----------------  -----------   ---------------
                                                                                            
Bernard L. Kasten, M.D.                       2005        250,000               --               --               --
Chief Executive Officer (1)                   2004        113,636               --               --        2,500,000
                                              2003             --               --               --               --

Thomas N. Konatich                            2005        230,000               --           35,000               --
Chief Financial Officer (2)                   2004        218,485               --           50,000          150,000
                                              2003        210,000               --               --               --

Dennis E. Hruby, Ph.D.                        2005        225,000               --          112,500               --
Chief Scientific Officer                      2004        213,363               --           63,000          150,000
                                              2003        210,000               --               --               --


(1)   Dr.  Kasten became Chief  Executive  Officer in the third quarter of 2004.
      His annual salary was $250,000.  Dr.  Kasten  resigned as Chief  Executive
      Officer of SIGA effective as of April 30, 2006.

(2)   Mr.  Konatich was appointed to serve in an  additional  capacity as Acting
      Chief Executive Officer effective as of May 1, 2006.

Option Grants for the Year Ended December 31, 2005

No options  were granted  during the year ended  December 31, 2005 to anyone who
served as Chief Executive Officer and its three highest paid employees.


                                       14


Option Exercises in Last Fiscal Year and Fiscal Year-End Option Values

      The following table provides certain summary information  concerning stock
options held as of December 31, 2005 by SIGA's Chief  Executive  Officer and its
three most highly compensated executive officers, other than its Chief Executive
Officer. No options were exercised during fiscal 2005 by any of the officers.



                                                                        Value of Unexercised
                                  Number of Securities Underlying       In-The-Money Options
                                       Unexercised Options #         At fiscal Year-End ($) (1)
                                       ---------------------         --------------------------
                                    Exercisable   Unexercisable     Exercisable    Unexercisable
                                    -----------   -------------     -----------    -------------
                                                                               
      Bernard L. Kasten, M.D.         933,332       1,666,668              --              --

      Thomas N. Konatich              545,000              --              --              --

      Dennis E. Hruby, Ph.D.          550,000          75,000              --              --


(1)   Based upon the closing  price on  December  31,  2005,  as reported on the
      Nasdaq SmallCap Market and the exercise price per option.

Long-Term Incentive Plans--Awards in Last Fiscal Year

      As of January 1, 1996,  we adopted our 1996  Incentive  and  Non-Qualified
Stock Option Plan. An amendment and  restatement  of such plan, as amended,  was
adopted on May 3, 2001 and was further refined by the Board of Directors on June
29, 2001 (the "Plan").  The Plan was approved by our  stockholders  at an annual
meeting on August 15,  2001,  and amended on January 8, 2004,  to  increase  the
maximum  number of shares of common stock  available for issuance under the Plan
to 10,000,000.  Stock options may be granted to key employees,  consultants  and
outside directors pursuant to the Plan. The Plan was amended again at our annual
meeting on May 26,  2005,  when our  stockholders  voted to increase the maximum
number of shares of common  stock  available  for  issuance  under the Plan from
10,000,000 to 11,000,000.

      The Plan is administered by our  Compensation  Committee which  determines
persons to be granted stock  options,  the amount of stock options to be granted
to each such  person,  and the  terms and  conditions  of any stock  options  as
permitted under the Plan. The members of the  Compensation  Committee are Mehmet
C. Oz, M.D.,  Paul G. Savas and Donald G. Drapkin.  See "Committees of the Board
of Directors" above for more information.

      Both Incentive  Options and Nonqualified  Options may be granted under the
Plan.  An Incentive  Option is intended to qualify as an incentive  stock option
within the  meaning of Section  422 of the  Internal  Revenue  Code of 1986,  as
amended (the "Code").  Any Incentive  Option granted under the Plan will have an
exercise  price of not less than 100% of the fair market  value of the shares on
the date on which such option is granted.  With respect to an  Incentive  Option
granted to an employee who owns more than 10% of the total combined voting stock
of SIGA or of any parent or  subsidiary  of SIGA,  the  exercise  price for such
option must be at least 110% of the fair market  value of the shares  subject to
the option on the date the option is granted.

      The Plan,  as amended,  provides  for the  granting of options to purchase
11,000,000  shares of common stock, of which 9,399,561  options were outstanding
as of December 31, 2005.


                                       15


      During the fiscal year ending  December 31, 2005, the named  Directors and
Officers of SIGA received  long-term  incentive  compensation  under the Plan as
shown in the following table.



         (a)                      (b)                  (c)                (d)              (e)               (f)
         ---                      ---                  ---                ---              ---               ---
                                                                             Estimated Future Payouts Under
                               Number of          Performance or               Non-Stock Price Based Plans
                            Shares, Units or    Other Period Until             ---------------------------
                              Other Rights         Maturation of       Threshold          Target          Maximum
Name                              (#)                 Payout            ($ or #)         ($ or #)         ($ or #)
----                              ---                 ------            --------         --------         --------
                                                                                              
Donald G. Drapkin                10,000              6/2/2015              N/A              N/A              N/A
James J. Antal                   10,000              6/2/2015              N/A              N/A              N/A
Thomas E. Constance              10,000              6/2/2015              N/A              N/A              N/A
Adnan M. Mjalli, Ph.D.           10,000              6/2/2015              N/A              N/A              N/A
Mehmet C. Oz, M.D.               10,000              6/2/2015              N/A              N/A              N/A
Eric A. Rose, M.D.               10,000              6/2/2015              N/A              N/A              N/A
Paul G. Savas                    10,000              6/2/2015              N/A              N/A              N/A
Judy S. Slotkin                  10,000              6/2/2015              N/A              N/A              N/A
Michael Weiner, M.D.             10,000              6/2/2015              N/A              N/A              N/A


Employment Contracts and Directors Compensation

Directors' Compensation

      Directors  who are not  currently  receiving  compensation  as officers or
employees of the Company or any of its affiliates receive $1,000 per meeting for
board  meetings  and  will  be  reimbursed  for  expenses  incurred  by  them in
connection  with  serving on our Board of  Directors.  The chairman of the Audit
Committee  will receive  $1,000 per meeting for meetings of the Audit  Committee
and all other members of the Audit  Committee  will receive $500 per meeting for
meetings  of  the  Audit  Committee.   Members  of  Compensation  Committee  and
Nominating and Corporate  Governance Committee will receive $500 per meeting for
meetings of the Compensation  Committee and Nominating and Corporate  Governance
Committee.

      Non-employee  directors  will receive an initial grant of 25,000  options,
upon such  non-employee  director's  first  election to the Board of  Directors,
which such  options  will be granted  under  SIGA's  Amended and  Restated  1996
Incentive  and  Non-Qualified  Stock  Option  Plan.  In  addition,  non-employee
directors  will receive an annual grant of 10,000  options under SIGA's  Amended
and Restated 1996 Incentive and  Non-Qualified  Stock Option Plan,  made at each
Annual Meeting and  commencing  with the 2005 Annual  Meeting.  All such options
have an exercise  price equal to the fair market  value of the  underlying  SIGA
shares on the date of grant.


                                       16


Equity Compensation Plan Information

      The following table sets forth certain  compensation plan information with
respect to both equity  compensation  plans  approved  by  security  holders and
equity  compensation  plans not approved by security  holders as of December 31,
2005:



                                                                                         Number of securities
                                                                                        remaining available for
                                      Number of securities                               future issuance under
                                        to be issued upon        Weighted-average         equity compensation
                                           exercise of           exercise price of         plans (excluding
                                      outstanding options,     outstanding options,     securities reflected in
Plan Category                          warrants and rights      warrants and rights           column (a))
                                               (a)                      (b)                       (c)
                                                                                      

Equity compensation plans
approved by security holders (1)             9,399,561                 $2.00                   1,385,398

Equity compensation plans not
approved by security holders                   250,000                 $2.00                          --

Total                                        9,649,561                 $2.00                   1,385,398


(1)   SIGA   Technologies,   inc.,  Amended  and  Restated  1996  Incentive  and
      Non-Qualified Stock Option Plan.

Employment Contracts

      Dr. Bernard L. Kasten,  SIGA's Chief  Executive  Officer,  was employed by
SIGA under an employment  agreement  dated July 2, 2004. Dr. Kasten  received an
annual base salary of $250,000 and his  employment  agreement  also provided for
additional  bonus payments at the discretion of the Board of Directors.  On July
2, 2004, he received  options to purchase  2,500,000 shares of common stock with
an exercise price of $1.30 per share, of which 500,000 shares vested on the date
of grant;  with respect to the next  1,000,000  shares,  an  additional  166,666
shares  vested on the end of each six (6) month period after date of grant until
the end of the sixth six (6) month period at which time  166,667  shares were to
vest. Effective April 30, 2006, SIGA and Dr. Kasten reached an agreement for Dr.
Kasten's resignation. In connection with such agreed upon resignation,  SIGA and
Dr.  Kasten  entered  into a  Separation  Agreement  dated  March 31,  2006 (the
"Separation  Agreement").  Under the provisions of the Separation Agreement, Dr.
Kasten  received his salary on the existing terms and conditions as set forth in
his  Employment  Agreement  with  SIGA,  dated  July 2,  2004  (the  "Employment
Agreement")  in lieu of any other  severance or payment,  through  September 16,
2006  (the  "Separation  Period").   Concurrently  with  the  execution  of  the
Separation  Agreement,  SIGA and Dr. Kasten also amended Dr. Kasten's  Incentive
Stock Option Agreement such that Dr. Kasten's  "Milestone Options" (as such term
is defined in the Employment  Agreement)  were cancelled and Dr.  Kasten's "Time
Vested  Options"  (as such term is defined  in the  Employment  Agreement)  were
amended such that with respect to the Time Vested  Options which have not vested
as of the date of the Separation  Agreement,  such options will vest as follows:
with  respect  to  166,666  shares  as of July 2, 2006 and with  respect  to the
remaining  83,334 shares,  as of January 2, 2007. Time Vested Options granted to
Dr. Kasten which have vested prior to the date of the Separation Agreement shall
remain  unchanged.  Dr.  Kasten  will also be  permitted  to continue to receive
medical and/or dental insurance benefits under the relevant SIGA plans until (i)
the end of the Remaining Tenure (defined as the earlier of April 30, 2006 or Dr.
Kasten's  obtaining  new  employment),  (ii) he becomes  entitled to Medicare or
(iii) he becomes  eligible for coverage  under medical  and/or dental  insurance
benefit  plans,  as the case may be, of  another  employer  through  his  future
employment,  whichever  occurs first.  The  Separation  Agreement  also contains
mutual  non-disparagement  and release  terms,  requires  that Dr. Kasten remain
available to SIGA on a reasonable  basis for  transitional  purposes  during the
Separation  Period and requires  SIGA to indemnify Dr. Kasten under the terms of
its certificate of incorporation and bylaws for acts relating to his employment.


                                       17


      Thomas N. Konatich, SIGA's Acting Chief Executive Officer, Vice President,
Chief Financial Officer,  Secretary and Treasurer,  is employed by SIGA under an
employment  agreement  dated April 1, 1998,  as amended on January 19, 2000,  as
amended and restated on October 6, 2000,  as amended as of January 31, 2002,  as
amended  on  November  5, 2002,  as  amended on July 29,  2004 and as amended on
February  1, 2006.  This  employment  agreement  expires on June 30,  2007.  Mr.
Konatich has previously  also served as SIGA's Acting Chief  Executive  Officer,
which duties  concluded on July 2, 2004.  Mr.  Konatich  receives an annual base
salary of $230,000  and  received a one-time  payment of $50,000 for his initial
service  as Acting  Chief  Executive  Officer.  His  employment  agreement  also
provides  for an  additional  bonus  payment at the  discretion  of the Board of
Directors  and not to exceed 25% of his annual base salary  amount.  He received
options to purchase  95,000 shares of common  stock,  at $4.44 on April 1, 1998.
The options  vested on a pro rata basis on the first,  second,  third and fourth
anniversaries  of the agreement.  On January 19, 2000, he received an additional
grant to purchase 100,000 shares at an exercise price of $2.00 per share.  These
options  vest on a pro rata basis each  quarter  through  January 19,  2002.  On
January 31,  2002,  Mr.  Konatich  was granted an  "Incentive  Stock  Option" to
purchase  50,000  shares at an exercise  price of $3.94 per share.  Such options
vest in eight equal  quarterly  installments  beginning  on April 20,  2002.  On
November 5, 2002, Mr. Konatich was granted an Incentive Stock Option to purchase
150,000 shares at an exercise price of $2.50 per share.  75,000 of these options
vested  immediately  and 75,000 options vested on September 1, 2003. On July 29,
2004,  Mr.  Konatich was granted an Incentive  Stock Option to purchase  150,000
shares at an exercise  price of $1.40 per share.  75,000 of these options vested
immediately  and with the remaining  75,000 options  vesting on a pro rata basis
from  January  1,  2005  through   December  31,  2005  with  no  provision  for
acceleration under any  circumstances.  Mr. Konatich is also eligible to receive
additional  stock  options  and  bonuses  at  the  discretion  of the  Board  of
Directors. SIGA may terminate the employment agreement with or without cause (as
such  term is  defined  in the  employment  agreement),  provided  that upon any
termination  without  cause,  SIGA  will be  obligated  to  continue  to pay Mr.
Konatich's  salary and all other amounts due under the employment  agreement for
the  remainder of the term.  If Mr.  Konatich is  terminated  due to a change of
control (as such term is defined in the employment agreement),  SIGA is required
to pay Mr.  Konatich a change in control  amount (as such term is defined in the
employment  agreement)  plus his accrued and unpaid base salary,  and,  upon the
first  event  constituting  a change of  control,  all stock  options  and other
stock-based  grants to Mr. Konatich shall  immediately and irrevocably  vest and
become exercisable upon the date of such event.

      Dr. Dennis E. Hruby, Chief Scientific  Officer,  is employed by SIGA under
an employment  agreement  dated January 1, 1998, as amended on June 16, 2000, as
amended on  January  31,  2002,  as amended on October 3, 2002 and as amended on
July 29, 2004. This employment agreement expires on December 31, 2007. Dr. Hruby
receives a base salary of $225,000 per year and his  employment  agreement  also
provides  for  additional  bonus  payments  at the  discretion  of the  Board of
Directors and not to exceed 50% of his base salary  amount.  Dr. Hruby  received
options to purchase  10,000 shares of common stock at an exercise price of $5.00
per share on April 1, 1997 and  40,000  shares  of common  stock at an  exercise
price of $4.63 per share on April 1, 1998. The options  became  exercisable on a
pro rata  basis on the first,  second,  third and  fourth  anniversaries  of the
agreement.  Under the June 16, 2000 amendment,  Dr. Hruby was granted options to
purchase  125,000 shares of SIGA's common stock at $2.00 per share.  The options
vest  ratably over the  remaining  term of the  amendment.  The January 31, 2002
amendment  changed  the  terms of the  lock-up  agreed  to in the June 16,  2000
amendment to the  employment  agreement  limiting  Hruby's  ability to sell SIGA
stock. On January 31, 2002, Dr. Hruby was granted an "Incentive Stock Option" to
purchase  50,000  shares at an exercise  price of $3.94 per share.  Such options
vest in four equal annual installments  beginning on August 15, 2002. As part of
the  October 3, 2002  amendment,  Dr.  Hruby was  granted an option to  purchase
300,000  shares of common  stock.  Options with respect to 75,000  shares vested
upon the signing of the amendment and an additional  75,000 shares shall vest on
a pro rata basis on September 1 of each 2003, 2004 and 2005. The options have an
exercise price of $2.50 per share. Dr. Hruby  surrendered his option to purchase
up to 50,000  shares of common stock of SIGA at an exercise  price of $3.94 that
he was granted  under an earlier  amendment.  On July 29,  2004,  Dr.  Hruby was
granted an  Incentive  Stock  Option to purchase  150,000  shares at an exercise
price of $1.40 per share, which options shall vest in 75,000 share increments on
December 31 of each year, commencing December 31, 2005. Dr. Hruby is eligible to
receive  additional  stock options and bonuses at the discretion of the Board of
Directors. SIGA may terminate the employment agreement with or without cause (as
such  term is  defined  in the  employment  agreement),  provided  that upon any
termination  without cause SIGA will be obligated to continue to pay Dr. Hruby's
salary for the remainder of the term. In addition, SIGA shall have the right


                                       18


to terminate Dr. Hruby's  employment  upon one (1) year written notice with such
termination being treated as a termination for cause. If Dr. Hruby is terminated
due to a  change  of  control  (as  such  term  is  defined  in  the  employment
agreement), SIGA shall pay Dr. Hruby a change in control amount (as such term is
defined in the  employment  agreement)  plus his accrued and unpaid base salary,
and, upon the first event  constituting  a change of control,  all stock options
and other stock-based grants to Dr. Hruby shall immediately and irrevocably vest
and become exercisable upon the date of such event.


                                       19


         SECURITY OWNERSHIP OF CERTAIN BENEFICIAL OWNERS AND MANAGEMENT

      The  following  tables  set  forth  certain   information   regarding  the
beneficial  ownership of SIGA's voting  securities as of October 31, 2006 of (i)
each person  known to SIGA to  beneficially  own more than 5% of the  applicable
class of voting  securities,  (ii) each  director and director  nominee of SIGA,
(iii) each Named Officer and (iv) all  directors and executive  officers of SIGA
as a group. As of November 6, 2006, a total of 31,796,454 shares of Common Stock
were outstanding.  Each share of Common Stock is entitled to one vote on matters
on which  holders of Common  Stock are  eligible  to vote.  The column  entitled
"Percentage  of Total Voting Stock  Outstanding"  shows the  percentage of total
voting stock beneficially owned by each listed party.

      The  number  of  shares  beneficially  owned  is  determined  under  rules
promulgated by the Securities and Exchange  Commission,  and the  information is
not necessarily  indicative of beneficial ownership for any other purpose. Under
those rules, beneficial ownership includes any shares as to which the individual
has sole or shared  voting power or  investment  power and also any shares which
the  individual  has the right to acquire  within 60 days of October  31,  2006,
through the exercise or conversion of any stock  option,  convertible  security,
warrant or other right. Unless otherwise indicated,  each person or entity named
in the table has sole voting  power and  investment  power (or shares that power
with that person's spouse) with respect to all shares of capital stock listed as
owned by that person or entity.

                            Ownership of Common Stock

      The  following  tables  set  forth  certain   information   regarding  the
beneficial  ownership of SIGA's voting  securities as of October 31, 2006 of (i)
each person  known to SIGA to  beneficially  own more than 5% of the  applicable
class of voting  securities,  (ii) each  director and director  nominee of SIGA,
(iii) each Named  Officer,  and (iv) all  directors  and  officers  of SIGA as a
group. As of November 6, 2006, a total of 31,796,454 shares of common stock were
outstanding.  Each share of common  stock is  entitled to one vote on matters on
which common stockholders are eligible to vote. The column entitled  "Percentage
of Total Voting Stock" shows the  percentage of total voting stock  beneficially
owned by each listed party.



                                                                                    Percentage of          Percentage of
Name and Address of                                      Amount of Beneficial        Common Stock          Total Voting
Beneficial Owner (1)                                         Ownership (2)           Outstanding         Stock Outstanding
--------------------                                    ----------------------   -------------------   ---------------------
                                                                                                       
Beneficial Holders

MacAndrews & Forbes Inc. (3)
35 East 62nd Street
New York, NY 10021 ................................           5,620,771(4)               16.8%                  16.8%

Eliot Rose Asset Management, LLC
10 Weybosset Street
Suite 401
Providence, RI 02903 ..............................           3,216,500                  10.1%                  10.1%

TransTech Pharma, Inc.
4170 Mendenhall Oaks Parkway
High Point, NC 27265 ..............................           5,296,634(5)               15.8%                  15.8%

Officers and Directors

Donald G. Drapkin (6)
35 East 62nd Street
New York, NY 10021 ................................           1,808,326(7)                5.4%                   5.4%

James J. Antal
30952 Steeplechase Dr.
San Juan Capistrano, CA 94704 .....................              46,154(8)                  *                      *

Judy S. Slotkin (19)
888 Park Avenue
NY, NY 10021 ......................................              35,000(9)                  *                      *



                                       20




                                                                                    Percentage of          Percentage of
Name and Address of                                      Amount of Beneficial        Common Stock          Total Voting
Beneficial Owner (1)                                         Ownership (2)           Outstanding         Stock Outstanding
--------------------                                    ----------------------   -------------------   ---------------------
                                                                                                       
Thomas E. Constance
1177 Avenue of the Americas,
New York, NY 10036 ................................             263,467(10)                 *                      *

Bernard L. Kasten Jr., M.D.(11) ...................           1,712,360(12)               5.2%                   5.2%

Adnan M. Mjalli, Ph.D
4170 Mendenhall Oaks Parkway, Suite 110
High Point, NC 27265 ..............................              35,000(13)                 *                     --

Mehmet C. Oz, M.D.
177 Fort Washington Ave
New York, NY 10032 ................................             135,000(14)                 *                      *

Eric A. Rose, M.D. (15)
122 East 78th Street
New York, NY 10021 ................................             800,090(16)               2.5%                   2.5%

Paul G. Savas
35 East 62nd Street
New York, NY 10021 ................................              61,664(17)                 *                      *

Michael A. Weiner, M.D.
161 Fort Washington Ave.
New York, NY 10032 ................................             122,500(14)                 *                      *

Thomas N. Konatich ................................             545,000(18)               1.7%                   1.7%

Dennis E. Hruby, Ph.D. ............................             550,000(18)               1.7%                   1.7%

All Executive Officers and Directors as a
group (thirteen persons) ..........................           6,114,561(20)              16.5%                  16.5%


----------
* Less than 1%

(1)   Unless otherwise indicated the address of each beneficial owner identified
      is 420 Lexington Avenue, Suite 408, New York, NY 10170.

(2)   Unless  otherwise  indicated,  each person has sole  investment and voting
      power with respect to the shares indicated.  For purposes of this table, a
      person or group of persons is deemed to have "beneficial ownership" of any
      shares as of a given  date  which  such  person  has the right to  acquire
      within 60 days after such date.  For purposes of computing the  percentage
      of outstanding  shares held by each person or group of persons named above
      on a given date,  any security  which such person or persons has the right
      to acquire within 60 days after such date is deemed to be outstanding  for
      the  purpose of  computing  the  percentage  ownership  of such  person or
      persons,  but is not deemed to be outstanding for the purpose of computing
      the percentage ownership of any other person.

(3)   MacAndrews & Forbes Inc. is a direct wholly-owned subsidiary of MacAndrews
      & Forbes Holdings Inc., a holding company whose sole stockholder is Ronald
      O. Perelman.

(4)   Includes  1,764,206  shares of common  stock  issuable  upon  exercise  of
      warrants.

(5)   Includes  1,824,412  shares of common  stock  issuable  upon  exercise  of
      warrants.

(6)   Mr.  Drapkin  is a  director  and Vice  Chairman  of  MacAndrews  & Forbes
      Holdings  Inc.  and  MacAndrews  & Forbes Inc. and a director of TransTech
      Pharma.


                                       21


(7)   Includes  1,135,000  shares of common  stock  issuable  upon  exercise  of
      options,  shares of common  stock  underlying  a warrant to purchase up to
      347,826  shares of common  stock and shares of common  stock  underlying a
      warrant to  purchase  up to 30,500  shares of common  stock (the  "Drapkin
      September 2001 Investor  Warrant").  However,  the Drapkin  September 2001
      Investor  Warrant  provides that,  with certain limited  exceptions,  such
      warrant is not exercisable if, as a result of such exercise, the number of
      shares  of  common  stock  beneficially  owned  by  Mr.  Drapkin  and  his
      affiliates  (other  than  shares  of  common  stock  which  may be  deemed
      beneficially owned through the ownership of the unexercised portion of the
      Drapkin  September  2001  Investor  Warrant)  would  exceed  9.99%  of the
      outstanding  shares of common  stock.  Does not  include  shares of common
      stock that Mr. Drapkin,  as a director and Vice Chairman of Mafco Holdings
      Inc. and  MacAndrews & Forbes or as director of TransTech  Pharma,  may be
      deemed  to  beneficially  own  and  as  to  which  Mr.  Drapkin  disclaims
      beneficial ownership.

(8)   Includes 35,000 shares of common stock issuable upon exercise of options.

(9)   Includes 35,000 shares of common stock issuable upon exercise of options.

(10)  Includes  12,200  shares  issuable  upon  exercise of warrants and 235,000
      shares of common stock issuable upon exercise of options.

(11)  Dr.  Kasten  became our Chief  Executive  Officer in the third  quarter of
      2004. Dr. Kasten resigned as Chief Executive  Officer of SIGA effective as
      of April 30, 2006.

(12)  Includes  1,350 shares of common stock  issuable upon exercise of warrants
      and 1,350,000 shares of common stock issuable upon exercise of options.

(13)  Includes  35,000 shares of common stock issuable upon exercise of options.
      Does not include shares of common stock that Dr. Mjalli,  as a director of
      TransTech  Pharma,  may be deemed to beneficially  own and as to which Dr.
      Mjalli disclaims beneficial ownership.

(14)  Includes  12,500  shares  issuable  upon  exercise of warrants and 110,000
      shares issuable upon exercise of options.

(15)  Dr. Rose is a director of TransTech Pharma.

(16)  Includes  88,610 shares of common stock issuable upon exercise of warrants
      and 610,000 shares of common stock issuable upon exercise of options. Does
      not  include  shares of common  stock  that Dr.  Rose,  as a  director  of
      TransTech  Pharma,  may be deemed to beneficially  own and as to which Dr.
      Rose disclaims beneficial ownership.

(17)  Includes  9,303 shares of common stock  issuable upon exercise of warrants
      and 35,000 shares issuable upon exercise of options.

(18)  Neither of Messrs.  Konatich  and Hruby own  shares of common  stock.  All
      shares listed as beneficially owned by each of Messrs.  Konatich and Hruby
      are shares issuable upon exercise of stock options.

(19)  Does not include  35,605  shares of common  stock  owned by Ms.  Slotkin's
      spouse to which she disclaims beneficial ownership.

(20)  See footnotes (6)-(21).


                                       22


                 CERTAIN RELATIONSHIPS AND RELATED TRANSACTIONS

      Thomas E.  Constance,  a director of SIGA,  is  Chairman  of Kramer  Levin
Naftalis & Frankel LLP, a law firm in New York City,  which SIGA has retained to
provide legal services.

      Adnan M. Mjalli, a director of SIGA, is also President and Chief Executive
Officer of TransTech Pharma.


                                       23


                                 PROPOSAL NO. 2

                         RATIFICATION OF APPOINTMENT OF
                  INDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRM

      The Audit  Committee of the Board of Directors  has  appointed the firm of
PricewaterhouseCoopers  LLP as SIGA's  independent  registered public accounting
firm to audit  the  financial  statements  of SIGA for the  fiscal  year  ending
December 31, 2006, and recommends  that  stockholders  vote for  ratification of
this  appointment.  PricewaterhouseCoopers  LLP  has  audited  SIGA's  financial
statements since January 1997. Representatives of PricewaterhouseCoopers LLP are
expected to be present at the Annual  Meeting and will have the  opportunity  to
make a statement  if they desire to do so, and are  expected to be  available to
respond to  appropriate  questions.  The  affirmative  vote of a majority of the
total votes cast on such  proposal  in person or by proxy at the Annual  Meeting
will be required to ratify the selection of PricewaterhouseCoopers LLP.

      If the stockholders fail to ratify the selection, the Audit Committee will
reconsider  its selection of auditors.  Even if the  selection is ratified,  the
Audit  Committee,  in its discretion,  may direct the appointment of a different
independent registered public accounting firm at any time during the year, if it
determines  that  such  change  would be in the best  interests  of SIGA and its
stockholders.

Audit Fees

      PricewaterhouseCoopers  LLP billed  SIGA  $184,300 in the  aggregate,  for
professional  services rendered by them for the audit of SIGA's annual financial
statements for the fiscal year ended  December 31, 2005,  reviews of the interim
financial  statements  included in SIGA's Forms 10-Q filed during the year ended
December 31, 2005 and consents and reviews of various  documents  filed with the
SEC during the year ended December 31, 2005.

      PricewaterhouseCoopers  LLP billed  SIGA  $213,300 in the  aggregate,  for
professional  services rendered by them for the audit of SIGA's annual financial
statements for the fiscal year ended  December 31, 2004,  reviews of the interim
financial statements included in SIGA's Forms 10-QSB filed during the year ended
December 31, 2004 and consents and reviews of various  documents  filed with the
SEC during the year ended December 31, 2004.

Audit Related Fees

      There were no Audit Related Fees in 2005 and 2004.

Tax Fees

      PricewaterhouseCoopers  LLP did not render any  professional  services for
tax  compliance,  tax advice or tax planning  during  either of the fiscal years
ended December 31, 2005 or December 31, 2004.

All Other Fees

      PricewaterhouseCoopers  LLP did not  provide  any  products  or render any
professional  services  (other  than those  covered  above under  "Audit  Fees,"
"Audited  Related Fees," and "Tax Fees") during either of the fiscal years ended
December 31, 2005 or December 31, 2004.

Policy  on Audit  Committee  Pre-Approval  of Audit  and  Permissible  Non-Audit
Services of Independent Registered Public Accounting Firm

      The Audit  Committee's  policy is to pre-approve all audit and permissible
non-audit  services  provided by the independent  registered  public  accounting
firm.  These services may include audit services,  audit-related  services,  tax
services, and other services.


                                       24


      SIGA  did not  make  use in  fiscal  year  2005 of the  rule  that  waives
pre-approval  requirements  for non-audit  services in certain cases if the fees
for these services constitute less than 5% of the total fees paid to the auditor
during the year.

      THE BOARD OF DIRECTORS  RECOMMENDS  THAT THE  STOCKHOLDERS  VOTE "FOR" THE
RATIFICATION  (ITEM  2 OF  THE  ENCLOSED  PROXY  CARD)  OF  THE  APPOINTMENT  OF
PRICEWATERHOUSECOOPERS  LLP AS SIGA'S  INDEPENDENT  REGISTERED PUBLIC ACCOUNTING
FIRM FOR THE FISCAL YEAR ENDING DECEMBER 31, 2006.


                                       25




------------------------------------------------------------------------------------------------
                                   New Plan Benefits (1)
------------------------------------------------------------------------------------------------
Name and Position                  Additional Stock Options Granted     Dollar Value ($)
-----------------                  --------------------------------     ----------------
------------------------------------------------------------------------------------------------
                                                                   
Non-Executive Director Group       90,000 (2)                            325,800 (3)
------------------------------------------------------------------------------------------------


      (1)   All  other  future  benefits  under  the  Plan  will  be made at the
            discretion of SIGA's Compensation  Committee and,  accordingly,  are
            not determinable at this time.

      (2)   The  option  grants  reflected  in the table  above  will be made in
            accordance with SIGA's previously  disclosed  Director  Compensation
            Program.

      (3)   Current market price on the October 31, 2006.


                                       26


                              STOCKHOLDER PROPOSALS

      Stockholder  proposals  to be  presented  at the 2007  Annual  Meeting  of
Stockholders, for inclusion in SIGA's proxy statement and form of proxy relating
to that meeting,  must be received by SIGA at its offices in New York, New York,
addressed to the Secretary,  not later than January 1, 2007. Such proposals must
comply  with  SIGA's  By-Laws  and the  requirements  of  Regulation  14A of the
Securities Exchange Act of 1934 (the "Exchange Act").

      In  addition,  Rule 14a-4 of the  Exchange  Act governs  SIGA's use of its
discretionary proxy voting authority with respect to a stockholder proposal that
is not  addressed  in the proxy  statement.  With  respect to SIGA's 2007 Annual
Meeting  of  Stockholders,  if  SIGA is not  provided  notice  of a  stockholder
proposal prior to March 16, 2007, SIGA will be allowed to use its  discretionary
voting  authority  when the  proposal  is raised  at the  meeting,  without  any
discussion of the matter in the proxy statement.

                              SECTION 16 BENEFICIAL
                         OWNERSHIP REPORTING COMPLIANCE

      Section 16(a) of the Exchange Act requires  SIGA's officers and directors,
and persons who own more than ten percent of a registered class of SIGA's equity
securities,  to file  reports of  ownership  and changes in  ownership  with the
Securities  and  Exchange  Commission.  Officers,  directors  and  greater  than
ten-percent  stockholders  are required by  Securities  and Exchange  Commission
regulation  to furnish SIGA with copies of all Section  16(a)  reports that they
file.

      Based solely upon review of the copies of such  reports  furnished to SIGA
and  written  representations  from  certain of SIGA's  executive  officers  and
directors  that no other such reports were  required,  SIGA believes that during
the fiscal year ended December 31, 2005, no  individuals  failed to file reports
relating to any transaction as required by Section 16 of the Exchange Act.

           AVAILABILITY OF ANNUAL REPORT AND FORM 10-K TO STOCKHOLDERS

      SIGA's Annual Report to Stockholders  for the year ended December 31, 2005
accompanies  this proxy statement.  SIGA will provide to any  stockholder,  upon
written  request and without  charge,  a copy of its most recent  Report on Form
10-K,  including  the financial  statements,  as filed with the  Securities  and
Exchange  Commission.  All requests  for such reports  should be directed to the
Chief Financial  Officer,  420 Lexington  Avenue,  Suite 408, New York, New York
10170, telephone number (212) 672-9100.

                                  OTHER MATTERS

      At the date of this  proxy  statement,  management  was not aware that any
matters not referred to in this proxy statement would be presented for action at
the Annual Meeting.  If any other matters should come before the Annual Meeting,
the persons named in the accompanying proxy will have discretionary authority to
vote all  proxies  in  accordance  with their best  judgment,  unless  otherwise
restricted by law.

                                        BY ORDER OF THE BOARD OF DIRECTORS


                                       /s/ Thomas N. Konatich
                                       ----------------------

                                       Thomas N. Konatich
                                       Secretary

Dated: November 17, 2006


                                       27


                             SIGA TECHNOLOGIES, INC.
                    PROXY SOLICITED BY THE BOARD OF DIRECTORS
                     FOR THE ANNUAL MEETING OF STOCKHOLDERS
                         TO BE HELD ON DECEMBER 19, 2006

      The  undersigned  hereby appoints Thomas N. Konatich as attorney and proxy
of the undersigned,  with full power of substitution,  to vote all of the shares
of stock of SIGA  Technologies,  Inc. which the  undersigned  may be entitled to
vote at the Annual Meeting of Stockholders of SIGA Technologies, Inc. to be held
at the  offices of Kramer  Levin  Naftalis  & Frankel  LLP,  1177  Avenue of the
Americas,  29th floor, New York, New York 10036, on Tuesday,  December 19, 2006,
at 10:30 a.m. (local time), and at any and all postponements,  continuations and
adjournments  thereof,  with all powers that the  undersigned  would  possess if
personally  present,  upon  and in  respect  of  the  following  matters  and in
accordance with the following  instructions,  with discretionary authority as to
any and all other matters that may properly come before the meeting.

UNLESS A  CONTRARY  DIRECTION  IS  INDICATED,  THIS  PROXY WILL BE VOTED FOR ALL
NOMINEES   LISTED   IN   PROPOSAL   NO.   1,   AND  FOR  THE   RATIFICATION   OF
PRICEWATERHOUSECOOPERS  LLP AS THE INDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRM
OF SIGA TECHNOLOGIES, INC. FOR THE FISCAL YEAR ENDING DECEMBER 31, 2006. AS MORE
SPECIFICALLY  DESCRIBED IN THE PROXY  STATEMENT.  IF SPECIFIC  INSTRUCTIONS  ARE
INDICATED, THIS PROXY WILL BE VOTED IN ACCORDANCE THEREWITH.

THE BOARD OF  DIRECTORS  RECOMMENDS A VOTE "FOR" THE  DIRECTOR  NOMINEES  LISTED
BELOW, AND "FOR" THE SELECTION OF PRICEWATERHOUSECOOPERS  LLP AS THE INDEPENDENT
REGISTERED PUBLIC ACCOUNTING FIRM OF SIGA TECHNOLOGIES, INC. FOR THE FISCAL YEAR
ENDING DECEMBER 31, 2006.

PLEASE VOTE,  SIGN,  DATE AND RETURN PROMPTLY IN THE ENCLOSED  ENVELOPE.  PLEASE
MARK YOUR VOTE IN BLUE OR BLACK INK AS SHOWN HERE: |X|

1.    To elect ten directors.

         |_|      FOR ALL NOMINEES

         |_|      WITHHOLD AUTHORITY FOR ALL NOMINEES

         |_|      FOR ALL EXCEPT (See instructions below)

         NOMINEES:      o     Donald G. Drapkin

                        o     Thomas E. Constance

                        o     Adnan M. Mjalli, Ph.D.

                        o     Mehmet C. Oz, M.D.

                        o     Eric A. Rose, M.D.

                        o     Paul G. Savas

                        o     Michael A. Weiner, M.D.




                        o     Judy S. Slotkin

                        o     James J. Antal

                        o     Scott M. Hammer, M.D.

      INSTRUCTION:  To withhold authority to vote for any individual nominee(s),
      mark "FOR ALL EXCEPT" and fill in circle next to each  nominee you wish to
      withhold, as shown here: |X|

2.    To ratify the selection of  PricewaterhouseCoopers  LLP as the independent
      registered  public  accounting  firm of SIGA  Technologies,  Inc.  for the
      fiscal year ending December 31, 2005.

      |_| FOR                |_| AGAINST               |_| ABSTAIN

THIS PROXY IS SOLICITED ON BEHALF OF THE BOARD OF  DIRECTORS.  IT MAY BE REVOKED
PRIOR TO ITS EXERCISE.

RECEIPT  OF  NOTICE  OF  THE  ANNUAL  MEETING  AND  PROXY  STATEMENT  IS  HEREBY
ACKNOWLEDGED,  AND THE  TERMS OF THE  NOTICE  AND  PROXY  STATEMENT  ARE  HEREBY
INCORPORATED BY REFERENCE INTO THIS PROXY.  THE  UNDERSIGNED  HEREBY REVOKES ALL
PROXIES  HERETOFORE  GIVEN  FOR  SAID  MEETING  OR  ANY  AND  ALL  ADJOURNMENTS,
POSTPONEMENTS AND CONTINUATIONS THEREOF.

PLEASE VOTE,  DATE,  SIGN AND PROMPTLY  RETURN THIS PROXY IN THE ENCLOSED RETURN
ENVELOPE WHICH IS POSTAGE PREPAID IF MAILED IN THE UNITED STATES.


-----------------------------------------------------------------

To  change  the  address  on your  account,  please  check  the box at right and
indicate your new address in the address  space above.  Please note that changes
to the  registered  name(s) on the account may not be submitted via this method.
|_|

Signature of Stockholder:_______________________________________________________
Date:____________________

Signature of Stockholder:_______________________________________________________
Date:____________________

PLEASE SIGN  EXACTLY AS YOUR NAME  APPEARS ON THIS PROXY.  WHERE SHARES ARE HELD
JOINTLY,  EACH HOLDER  SHOULD SIGN.  WHEN  SIGNING AS  EXECUTOR,  ADMINISTRATOR,
ATTORNEY-IN-FACT, TRUSTEE OR GUARDIAN, PLEASE GIVE FULL TITLE AS SUCH. IF SIGNER
IS A CORPORATION, PLEASE SIGN IN FULL CORPORATE NAME BY DULY AUTHORIZED OFFICER,
GIVING  FULL  TITLE AS SUCH.  IF SIGNER IS A  PARTNERSHIP,  PLEASE  SIGN IN FULL
PARTNERSHIP NAME BY AUTHORIZED PERSON.