UNITED STATES
SECURITIES AND EXCHANGE COMMISSION
WASHINGTON, D.C. 20549
SCHEDULE 13G
Under the Securities Exchange Act of 1934
(Amendment No. ___)
Biocryst Pharmaceuticals, Inc.
------------------------------
(Name of Issuer)
Common Stock, $.01 par value
----------------------------
(Title of Class of Securities)
09058V-10-3
-----------
(CUSIP Number)
October 20, 2006
----------------
(Date of Event which Requires Filing of this Statement)
Check the appropriate box to designate the rule pursuant to which
this Schedule is filed:
[ ] Rule 13d-1(b)
[x] Rule 13d-1(c)
[ ] Rule 13d-1(d)
*The remainder of this cover page shall be filled out for a
reporting person's initial filing on this form with respect to
the subject class of securities, and for any subsequent amendment
containing information which would alter the disclosures provided
in a prior cover page.
The information required in the remainder of this cover page
shall not be deemed to be "filed" for the purpose of Section 18
of the Securities Exchange Act of 1934 ("Act") or otherwise
subject to the liabilities of that section of the Act but shall
be subject to all other provisions of the Act (however, see the
Notes).
CUSIP No. 09058V-10-3 SCHEDULE 13G Page 2 of 11
1 Name of Reporting Person STEPHENS INVESTMENT MANAGEMENT, LLC
IRS Identification No. of Above Person 37-1453825
2 Check the Appropriate Box if a member of a Group (a) [ ]
(b) [ ]
3 SEC USE ONLY
4 Citizenship or Place of Organization DELAWARE
NUMBER OF 5 Sole Voting Power 1,538,218
SHARES
BENEFICIALLY 6 Shared Voting Power 0
OWNED BY EACH
REPORTING 7 Sole Dispositive Power 1,538,218
PERSON WITH
8 Shared Dispositive Power 0
9 Aggregate Amount Beneficially Owned by Each 1,538,218
Reporting Person
10 Check Box if the Aggregate Amount in Row (9) Excludes [ ]
Certain Shares
11 Percent of Class Represented by Amount in Row 9 5.3%
12 Type of Reporting Person OO
CUSIP No. 09058V-10-3 SCHEDULE 13G Page 3 of 11
1 Name of Reporting Person PAUL H. STEPHENS
IRS Identification No. of Above Person
2 Check the Appropriate Box if a member of a Group (a) [ ]
(b) [ ]
3 SEC USE ONLY
4 Citizenship or Place of Organization UNITED STATES
NUMBER OF 5 Sole Voting Power 1,793,218
SHARES
BENEFICIALLY 6 Shared Voting Power 0
OWNED BY EACH
REPORTING 7 Sole Dispositive Power 1,793,218
PERSON WITH
8 Shared Dispositive Power 0
9 Aggregate Amount Beneficially Owned by Each 1,793,218
Reporting Person
10 Check Box if the Aggregate Amount in Row (9) Excludes [ ]
Certain Shares
11 Percent of Class Represented by Amount in Row 9 6.1%
12 Type of Reporting Person IN/HC
CUSIP No. 09058V-10-3 SCHEDULE 13G Page 4 of 11
1 Name of Reporting Person P. BARTLETT STEPHENS
IRS Identification No. of Above Person
2 Check the Appropriate Box if a member of a Group (a) [ ]
(b) [ ]
3 SEC USE ONLY
4 Citizenship or Place of Organization UNITED STATES
NUMBER OF 5 Sole Voting Power 1,538,218
SHARES
BENEFICIALLY 6 Shared Voting Power 0
OWNED BY EACH
REPORTING 7 Sole Dispositive Power 1,538,218
PERSON WITH
8 Shared Dispositive Power 0
9 Aggregate Amount Beneficially Owned by Each 1,538,218
Reporting Person
10 Check Box if the Aggregate Amount in Row (9) Excludes [ ]
Certain Shares
11 Percent of Class Represented by Amount in Row 9 5.3%
12 Type of Reporting Person IN/HC
CUSIP No. 09058V-10-3 SCHEDULE 13G Page 5 of 11
1 Name of Reporting Person W. BRADFORD STEPHENS
IRS Identification No. of Above Person
2 Check the Appropriate Box if a member of a Group (a) [ ]
(b) [ ]
3 SEC USE ONLY
4 Citizenship or Place of Organization UNITED STATES
NUMBER OF 5 Sole Voting Power 1,538,218
SHARES
BENEFICIALLY 6 Shared Voting Power 0
OWNED BY EACH
REPORTING 7 Sole Dispositive Power 1,538,218
PERSON WITH
8 Shared Dispositive Power 0
9 Aggregate Amount Beneficially Owned by Each 1,538,218
Reporting Person
10 Check Box if the Aggregate Amount in Row (9) Excludes [ ]
Certain Shares
11 Percent of Class Represented by Amount in Row 9 5.3%
12 Type of Reporting Person IN/HC
CUSIP No. 09058V-10-3 SCHEDULE 13G Page 6 of 11
Item 1(a). Name of Issuer:
Biocryst Pharmaceuticals, Inc.
Item 1(b). Address of Issuer's Principal Executive Offices:
2190 Parkway Lake Drive
Birmingham, AL 35244
Item 2(a). Names of Persons Filing:
Stephens Investment Management, LLC ("SIM")
Paul H. Stephens ("Paul Stephens")
P. Bartlett Stephens ("Bart Stephens")
W. Bradford Stephens ("Brad Stephens")
Item 2(b). Address of Principal Business Office or, if none,
Residence:
The principal business address of each reporting person
is One Sansome Street, Suite 2900, San Francisco, CA 94104.
Item 2(c). Citizenship:
Reference is made to Item 4 of pages 2-5 of this Schedule
13G (this "Schedule"), which Items are incorporated by reference
herein.
Item 2(d). Title of Class of Securities:
Common Stock, $.01 par value
Item 2(e). CUSIP Number:
09058V-10-3
Item 3. If this statement is filed pursuant to Sections 240.13d-
1(b) or 240.13d-2(b) or (c), check whether the person
filing is a:
(a) [ ] Broker or dealer registered under section 15 of
the Act (15 U.S.C. 78o).
(b) [ ] Bank as defined in section 3(a)(6) of the Act (15
U.S.C. 78c).
(c) [ ] Insurance company as defined in section 3(a)(19)
of the Act (15 U.S.C. 78c).
CUSIP No. 09058V-10-3 SCHEDULE 13G Page 7 of 11
(d) [ ] Investment company registered under section 8 of
the Investment Company Act of 1940 (15 U.S.C. 80a-8).
(e) [ ] An investment adviser in accordance with Section
240.13d-1(b)(1)(ii)(E);
(f) [ ] An employee benefit plan or endowment fund
in accordance with Section 240.13d-1(b)(1)(ii)(F);
(g) [ ] A parent holding company or control person in
accordance with Section 240.13d-1(b)(1)(ii)(G);
(h) [ ] A savings associations as defined in Section 3(b)
of the Federal Deposit Insurance Act (12 U.S.C. 1813);
(i) [ ] A church plan that is excluded from the
definition of an investment company under section
3(c)(14) of the Investment Company Act of 1940 (15 U.S.C.
80a-3);
(j) [ ] Group, in accordance with Section 240.13d-
1(b)(1)(ii)(J).
Item 4. Ownership.
Reference is hereby made to Items 5-9 and 11 of pages 2-5
of this Schedule, which Items are incorporated by reference
herein.
Paul Stephens holds 255,000 shares of the Issuer's common
stock personally. The balance of shares reported as beneficially
owned by the reporting persons on this Schedule are held in
client accounts.
SIM, as general partner and investment manager of certain
client accounts, may be deemed to have the power to direct the
voting or disposition of the Issuer's common stock held by such
accounts. Therefore, SIM, as those accounts' general partner and
investment manager, and Paul Stephens, Brad Stephens and Bart
Stephens, as managing members and owners of SIM, may be deemed to
beneficially own the common stock owned by those accounts for the
purposes of Rule 13d-3 of the Securities Exchange Act of 1934, as
amended, insofar as they may be deemed to have the power to
direct the voting or disposition of that common stock.
CUSIP No. 09058V-10-3 SCHEDULE 13G Page 8 of 11
Neither the filing of this Schedule nor any of its
contents shall be deemed to constitute an admission that SIM,
Paul Stephens, Brad Stephens or Bart Stephens is, for any other
purpose, the beneficial owner of any securities to which this
Schedule relates, and each of SIM, Paul Stephens, Brad Stephens
and Bart Stephens disclaims beneficial ownership as to those
securities, except to the extent of his or its pecuniary
interests therein. Neither the filing of this Schedule nor any
of its contents shall be deemed to constitute an admission that
any of the other individual general partners, directors,
executive officers, and members of SIM is, for any purpose, the
beneficial owner of any of the securities to which this Schedule
relates, and such beneficial ownership is expressly disclaimed.
The calculation of percentage of beneficial ownership in
item 11 of pages 2-5 was derived from the Issuer's Quarterly
Report on Form 10-Q filed with the Securities and Exchange
Commission on November 9, 2006, in which the Issuer stated that
the number of shares of common stock, $.01 par value, outstanding
as of November 1, 2006 was 29,233,888.
Item 5. Ownership of Five Percent or Less of a Class.
Not applicable.
Item 6. Ownership of More Than Five Percent on Behalf of Another
Person.
SIM serves as general partner and investment manager to
certain client accounts that have the right to receive or the
power to direct the receipt of dividends from, or the proceeds
from the sale of, the Issuer's common stock. Other than as
reported in this Schedule, no individual client's holdings exceed
five percent of that common stock.
Item 7. Identification and Classification of the Subsidiary
Which Acquired the Security Being Reported on by the Parent
Holding Company.
Not applicable.
Item 8. Identification and Classification of Members of the
Group.
Not applicable.
Item 9. Notice of Dissolution of Group.
Not applicable.
CUSIP No. 09058V-10-3 SCHEDULE 13G Page 9 of 11
Item 10. Certifications.
By signing below I certify that, to the best of my
knowledge and belief, the securities referred to above were not
acquired and are not held for the purpose of or with the effect
of changing or influencing the control of the issuer of the
securities and were not acquired and are not held in connection
with or as a participant in any transaction having that purpose
or effect.
Signature
After reasonable inquiry and to the best of my knowledge
and belief, the undersigned certifies that the information set
forth in this statement is true, complete and correct.
Dated: February 9, 2007 STEPHENS INVESTMENT MANAGEMENT, LLC
By: /s/ W. Bradford Stephens
------------------------
W. Bradford Stephens
Its Managing Member
/s/ W. Bradford Stephens
------------------------
W. Bradford Stephens
/s/ P. Bartlett Stephens
------------------------
P. Bartlett Stephens
/s/ Paul H. Stephens
--------------------
Paul H. Stephens
CUSIP No. 09058V-10-3 SCHEDULE 13G Page 10 of 11
EXHIBIT INDEX
Exhibit A Joint Filing Undertaking Page 11
CUSIP No. 09058V-10-3 SCHEDULE 13G Page 11 of 11
EXHIBIT A
JOINT FILING UNDERTAKING
The undersigned, being authorized thereunto, hereby
execute this agreement as an exhibit to this Schedule 13G to
evidence the agreement of the below-named parties, in accordance
with rules promulgated pursuant to the Securities Exchange Act of
1934, to file this Schedule, as it may be amended, jointly on
behalf of each of such parties.
Dated: February 9, 2007 STEPHENS INVESTMENT MANAGEMENT, LLC
By: /s/ W. Bradford Stephens
------------------------
W. Bradford Stephens
Its Managing Member
/s/ Paul H. Stephens
--------------------
Paul H. Stephens
/s/ W. Bradford Stephens
------------------------
W. Bradford Stephens
/s/ P. Bartlett Stephens
------------------------
P. Bartlett Stephens