UNITED STATES
                       SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549
                           __________________________


                                    FORM 8-K

                                 CURRENT REPORT
                     Pursuant to Section 13 or 15(d) of the
                         Securities Exchange Act of 1934


        Date of report (Date of earliest event reported): October 5, 2004

                                   __________


                             SIGA Technologies, Inc.
               (Exact Name of Registrant as Specified in Charter)

            Delaware                    0-23047                13-3864870
            --------                    -------                ----------

 (State or other Jurisdiction of    (Commission File         (I.R.S. Employer
 Incorporation or Organization)          Number)          Identification Number)


      420 Lexington Avenue, Suite 601, New York, New York              10170
      ---------------------------------------------------              -----
         (Address of Principal Executive Offices)                    (Zip Code)


                                 (212) 672-9100
                                 --------------
              (Registrant's telephone number, including area code)



ITEM 7.01.  Regulation FD Disclosure.
            ------------------------

      On October 5, 2004, SIGA Technologies, Inc., a Delaware corporation,
issued a press release pursuant to which it announced that the Company's lead
smallpox compound, SIGA-246, has demonstrated significant antiviral activity
against several mouse models of poxvirus disease. A copy of the press release is
attached hereto as Exhibit 99.1, which is incorporated in this Item 7.01 by
reference.


ITEM 9.01   Financial Statements and Exhibits
            ---------------------------------

(c)   Exhibits

      Exhibit No.       Description
      -----------       -----------

      99.1              Press Release dated October 5, 2004.





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                                   SIGNATURES


      Pursuant to the requirements of the Securities Exchange Act of 1934, the
registrant has duly caused this report to be signed on its behalf by the
undersigned hereunto duly authorized.

                                    SIGA TECHNOLOGIES, INC.


                                    By: /s/ Thomas N. Konatich
                                       ----------------------------
                                       Thomas N. Konatich
                                       Chief Financial Officer

Date: October 5, 2004





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                                  EXHIBIT INDEX
                                  -------------

Exhibit Number    Description
--------------    -----------

    99.1          Press Release dated October 5, 2004.





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