UNITED STATES
                       SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549

                                    FORM 8-K


                                 CURRENT REPORT

                     Pursuant to Section 13 or 15(d) of the
                         Securities Exchange Act of 1934

                Date of Report (Date of earliest event reported)
                               September 20, 2006

                           HEMISPHERX BIOPHARMA, INC.
             (Exact name of registrant as specified in its charter)

                           Delaware 0-27072 52-0845822
               (state or other juris- (Commission (I.R.S. Employer
           diction of incorporation) File Number) (Identification No.)

              1617 JFK Boulevard, Philadelphia, Pennsylvania 19103
               (Address of principal executive offices) (Zip Code)

       Registrant's telephone number, including area code: (215) 988-0080


          (Former name or former address, if changed since last report)


Check  the  appropriate  box  below  if the  Form  8-K  filing  is  intended  to
simultaneously  satisfy the filing obligation of the registrant under any of the
following provisions (see General Instruction A.2. below):

     [ ] Written  communications  pursuant to Rule 425 under the  Securities Act
(17 CFR 230.425)

     [ ] Soliciting  material pursuant to Rule 14a-12 under the Exchange Act (17
CFR 240.14a-12)

     [ ]  Pre-commencement  communications  pursuant to Rule 14d-2(b)  under the
Exchange Act (17 CFR 240.14d-2(b))

     [ ]  Pre-commencement  communications  pursuant to Rule 13e-4(c)  under the
Exchange Act (17 CFR 240.13e-4(c))






Section 4 - Matters Related to Accountants and Financial Statements


Item 4.01 Changes in The Registrant's Certifying Accountant.


The Registrant's Board of Directors, with the approval of the Registrant's audit
committee, on August 23, 2006 authorized the Registrant to invite proposals from
a select number of independent  accounting firms for the purpose of becoming the
Registrant's independent accounting firm.

BDO Seidman,  LLP ("BDO")  informed the Registrant on September 18, 2006 that it
will resign from the  client-auditor  relationship  with the Registrant no later
than the date of the Registrant's  filing of its Form 10-Q report for the period
ending  September  30, 2006.  BDO's  decision to resign was not  recommended  or
approved by the Registrant's Audit Committee.

BDO's  reports on financial  statements of the  Registrant  for the fiscal years
ended  December  31,  2004 and  December  31,  2005 did not  contain any adverse
opinion or any  disclaimer  of opinion and were not  qualified or modified as to
uncertainty, audit scope or accounting principles.

During the fiscal years ended  December 31, 2004 and December 31, 2005,  and the
subsequent  interim periods  preceding the notice,  there were no  disagreements
between  the  Registrant  and BDO on any  matter  of  accounting  principals  or
practice,  financial statement  disclosure or auditing scope of procedure which,
if not  resolved  to the  satisfaction  of BDO,  would have caused BDO to make a
reference  to the subject  matter  thereof in  connection  with its reports and,
during  the same  period,  there  were no  reportable  events as defined in item
304(a)(1)(v) of the Commission  Regulation S-K, except as previously reported in
Item 9A of the Registrant's 2005 Form 10-K/A2.

Section 9 - Financial Statements and Exhibits Item 9.01 Financial Statements and
Exhibits.

(c)      Exhibits


Exhibit No.      Description

16               Letter on change in certifying accountant. *

------------------------------------------------
*To be filed by amendment.





                                   SIGNATURES


         Pursuant to the  requirements  of the Securities  Exchange Act of 1934,
the  registrant  has duly  caused  this report to be signed on its behalf by the
undersigned hereunto duly authorized.


                                       HEMISPHERX BIOPHARMA, INC.


September 20, 2006                     By:     /s/ Robert Peterson
                                       ----------------------------------
                                       Robert Peterson, Chief Financial Officer