UNITED STATES
                       SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549

                                  SCHEDULE 14A
Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934
                                (Amendment No. )

Filed by the Registrant [X]
Filed by a Party other than the Registrant [ ]
Check the appropriate box:
[ ]  Preliminary Proxy Statement
[ ]  Confidential, for Use of the Commission Only (as permitted by Rule
     14a-6(e)(2))
[ ]  Definitive Proxy Statement
[X]  Definitive Additional Materials
[ ]  Soliciting Material Under Rule 14a-12

                                 EXEGENICS INC.
--------------------------------------------------------------------------------
                (Name of Registrant as Specified In Its Charter)

--------------------------------------------------------------------------------
    (Name of Person(s) Filing Proxy Statement, if other than the Registrant)

Payment of Filing Fee (Check the appropriate box): [X] No fee required.
[ ] Fee computed on table below per Exchange Act Rules 14a-6(i)(1) and 0-11.

      1)   Title of each class of securities to which transaction applies:

           ---------------------------------------------------------------------
      2)   Aggregate number of securities to which transaction applies:

           ---------------------------------------------------------------------
      3)   Per unit price or other underlying value of transaction computed
           pursuant to Exchange Act Rule 0-11 (set forth the amount on which the
           filing fee is calculated and state how it was determined):

           ---------------------------------------------------------------------
      4)   Proposed maximum aggregate value of transaction:

           ---------------------------------------------------------------------
      5)   Total fee paid:

           ---------------------------------------------------------------------

[ ] Fee paid previously with preliminary materials.
[ ] Check box if any part of the fee is offset as provided by Exchange Act
    Rule 0-11(a)(2) and identify the filing for which the offsetting fee was
    paid previously. Identify the previous filing by registration statement
    number, or the Form or Schedule and the date of its filing:

           1)  Amount previously paid:

           ---------------------------------------------------------------------
           2)  Form, Schedule or Registration Statement No:

           ---------------------------------------------------------------------
           3)  Filing party:

           ---------------------------------------------------------------------
           4)  Date Filed:




                           [EXEGENICS INC. LETTERHEAD]

                             PROTECT YOUR INVESTMENT
                                       BY
                 VOTING THE ENCLOSED WHITE REVOCATION CARD TODAY

November 26, 2003

Dear eXegenics Stockholder:

We again urge you to protect your investment by supporting your incumbent Board
and rejecting the Meyers-Weiss Group's attempt to take control of eXegenics.

THE MEYERS-WEISS GROUP WANTS TO SEIZE CONTROL OF YOUR COMPANY, BUT IT IS
OFFERING YOU:

      o  NO PREMIUM for your shares;

      o  NO PLAN for how to enhance value for your investment;

      o  NO CLEAR QUALIFICATIONS for running eXegenics

INSTITUTIONAL SHAREHOLDER SERVICES (ISS) - a leading provider of proxy advisory
services to pension funds, foundations and other institutional investors - has
recommended that eXegenics stockholders support their incumbent Board and reject
the Meyers-Weiss Group's attempt to take control of eXegenics. In making this
recommendation, ISS points out the following in its proxy analysis: According to
ISS, THE MEYERS-WEISS GROUP'S NOMINEES "DO NOT HAVE ADEQUATE INDUSTRY EXPERIENCE
TO ADD VALUE" FOR EXEGENICS, AND HAVE "FAILED TO PRESENT A DETAILED, SPECIFIC
BUSINESS PLAN" FOR YOUR COMPANY.

The Meyers-Weiss Group's nominees include:

      o  The head of a check cashing business who formerly distributed
         "blank t-shirts"

      o  The head of a manufacturer of digital signal processing equipment.

      o  An orthopedic surgeon with no evident business experience.

             YOUR BOARD IS THE RIGHT TEAM WITH THE RIGHT EXPERIENCE

In contrast, your Board has relevant industry and financial experience that we
believe is crucial to the future success of eXegenics:

      o  Joseph M. Davie, M.D., Ph.D., a nationally renowned professor at
         Washington University Medical School who subsequently held key senior
         management positions at both Biogen (Senior Vice President, Head of
         Research) and G.D. Searle & Co. (President of R&D);

      o  Robert Easton, a noted consultant who previously served as a Managing
         Director with IBM Healthcare Consulting, has 30+ years of relevant
         experience, having worked with numerous clients in the pharmaceutical
         and biotech industries in his distinguished career;

      o  Walter M. Lovenberg, Ph.D., has had a distinguished career in the
         pharmaceutical and biotech industries, including over 20 years at the
         U.S. National Institutes of Health (where he served as Chief of
         Biochemical Pharmacology), then as a Director of Marion Merrell Dow
         (where he also headed their global research endeavors as Executive Vice
         President), and most recently as a member of the Boards of several
         prominent companies in our industry;





      o  Gordon Martin, MBA, CPA, brings impeccable credentials in finance,
         having served as Senior Accountant at Price Waterhouse prior to taking
         on positions of increasing responsibility at Marine Midland Bank,
         Westpac Banking Corporation, CIBC World Markets (Managing Director) and
         the NASDAQ Stock Market, Inc (Executive Vice President and Chief
         Financial Officer);

      o  Ronald L. Goode, Ph.D., eXegenics' Chairman, Chief Executive Officer
         and President, previously held a number of key senior management
         positions at G.D. Searle & Co., including President of Asia/Pacific
         World Area and President of Searle International. Prior to joining G.D.
         Searle, Dr. Goode was Vice President of Clinical Research and
         Scientific Affairs at Pfizer Pharmaceuticals.

                      YOUR BOARD HAS A PLAN AND A STRATEGY

Your Board believes there are attractive opportunities to enhance the value of
eXegenics shares by redeploying our assets to become a commercially-oriented
specialty markets drug company. Our plan is to focus on chronic disease medical
markets with fewer than 200,000 patients in the United States, and then to build
a value-added base of clinical assets, for which we will out-license
co-development and co-marketing rights.

Long-term, our strategy is to expand our clinical development portfolio and
commercialize our own products through a combination of licensing and
acquisition activity. We see multiple niche opportunities advantageous to
eXegenics for projects that are too specialized for large pharmaceutical
collaborations.

Drug development is inherently risky and there can be no guarantee that your
Board's strategy will be successful. Nevertheless, your Board does have a
specific plan and strategy for going forward, and deep industry and financial
expertise to leverage in pursuit of its plan. This is in stark contrast to the
Meyers-Weiss Group.

                  VOTE TO PROTECT THE FUTURE OF YOUR INVESTMENT

            SIGN, DATE AND RETURN THE ENCLOSED WHITE REVOCATION CARD

We urge you to protect your investment from a self-interested group offering no
premium or plan for delivering value, and with handpicked nominees that have no
clear qualifications.

Whether or not you have previously returned a blue consent card, please sign,
date and return the enclosed white revocation card now to protect your best
interests. We appreciate your support, and we are resolved to continue to make
every effort to maximize value for all our investors.

Sincerely,

/s/ Ronald L. Goode

Ronald L. Goode
Chairman and Chief Executive Officer