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Alkermes plc: Products, Profitability and Growth May 2011 |
Certain statements in this presentation may constitute forward looking statements within the meaning of the Private Securities Litigation Reform Act of 1995, including but not limited to statements about the operational and financial benefits of the business combination. Forward-looking information is not a guarantee of future performance. Actual results may differ materially from those contained in the forward-looking information due to a number of factors including: (i) the ability to obtain required regulatory approval and stockholder consent, and to satisfy other conditions, required to consummate the merger; (ii) whether anticipated financial and operational benefits from the proposed merger will be realized within the expected time frame or at all; (iii) whether the businesses will be integrated successfully or whether such integration may be more difficult, time consuming or costly than expected; and (iv) the cost and outcome of potential litigation relating to the transaction. For additional factors, which could cause actual results to differ from expectations, reference is made to the reports filed by the company with the Securities and Exchange Commission under the Securities Exchange Act of 1934, as amended. |
Important Additional Information and Where to Find It This communication does not constitute an offer to sell, or the solicitation of an offer to sell, or the solicitation of an offer to subscribe for or buy, any securities nor shall there be any sale, issuance or transfer of securities in any jurisdiction in which such offer, solicitation or sale would be unlawful prior to or qualification under the securities laws of any such jurisdiction. In connection with the proposed merger, Alkermes plc will file with the SEC a registration statement on Form S-4 that will include a preliminary prospectus regarding the proposed merger and Alkermes will file with the SEC a proxy statement in respect of the proposed merger. After the registration statement has been declared effective by the SEC, a definitive proxy statement/prospectus will be mailed to Alkermes INVESTORS ARE URGED TO CAREFULLY READ THE PROXY STATEMENT/PROSPECTUS (INCLUDING ALL AMENDMENTS AND SUPPLEMENTS THERETO) AND OTHER DOCUMENTS RELATING TO THE MERGER FILED WITH THE SEC WHEN THEY BECOME AVAILABLE, BECAUSE THEY WILL CONTAIN IMPORTANT INFORMATION ABOUT ALKERMES, EDT AND THE PROPOSED MERGER. You may obtain a copy of the registration statement and the proxy statement/prospectus (when available) and other related documents filed by Alkermes and Elan with the SEC regarding the proposed merger as well as other filings containing information about Alkermes, Elan and the merger, free of charge, through the web site maintained by the SEC at www.sec.gov, by directing a request to Alkermes 852 Winter Street, Waltham, Massachusetts 02451, Attn: at (781) 609-6000 or by email to financial@alkermes.com. Copies of the proxy statement/prospectus and the filings with the SEC that will be incorporated by reference in the proxy statement/prospectus can also be obtained, when available, without charge, from Alkermes www.Alkermes.com website at under the heading Investor SEC Filings. Participants in Solicitation This communication is not a solicitation of a proxy from any Alkermes shareholder. Alkermes and its directors, executive officers and certain other members of management and employees may, however, be deemed to be participants in the solicitation of proxies in respect of the proposed merger. Information regarding the persons who may, under the rules of the SEC, be considered participants in the solicitation of proxies in respect of the proposed merger will be set forth in the registration statement and the proxy statement/prospectus when it is filed with the SEC. You can find information about Alkermes directors and executive officers in its obtain free copies of these documents as described above. |
Alkermes and EDT: A Transformational Transaction Financially Operationally o Immediate profitability on a o Global biopharmaceutical cash earnings basis and company with proven track expanding Adjusted EBITDA record of innovation margins o Leader in CNS product o Accretive transaction development o Growing revenues in excess o Operating at a new scale of $450 million annually ~1,200 employees Driven by five major R&D expertise based on commercial products with proprietary technologies long patent lives World-class manufacturing o Incorporated in Ireland in U.S. and Ireland |
Five Major Products Drive Long-Term Growth AMPYRA® (18% manufacturing and royalty rate) o Treatment to improve walking in patients with multiple sclerosis (MS) o Launched in U.S. in 2010, MAA filed in Europe o Patent life into 2026 VIVITROL® (Proprietary product) o Once-monthly injectable medication for alcohol and opioid dependence o Ramping launch in opioid indication o Patent life into 2029 BYDUREON (8% royalty rate) o First once-weekly GLP-1 for type 2 diabetes o CHMP recommendation for approval in Europe o Patent life into 2025 RISPERDAL® CONSTA® (10% manufacturing and royalty rate, ~7.5% net) o Leading long-acting injectable antipsychotic for schizophrenia/bipolar I disorder o Approved in >90 countries, $1.5 billion in end-market sales o Patent life into 2020 in U.S. / 2021 in Europe INVEGA® SUSTENNA® (Tiered royalty rates on par with RISPERDAL CONSTA net economics) o Long-acting injectable antipsychotic for schizophrenia o Approved in U.S. and Europe, recent UK launch o Patent life into 2019 COPYRIGHT © 2011 ALKERMES, INC. |
® AMPYRA® o Treatment to improve walking in patients with multiple sclerosis (MS) o Expands Alkermes therapeutic scope into MS o Launched in U.S. in 2010, MAA filed in Europe o Marketed by Acorda in U.S., partnered with Biogen Idec in Europe o Patent life into 2026 o 18% manufacturing and royalty rate |
® VIVITROL® o Once-monthly injectable medication for alcohol and opioid dependence o Currently launching opioid indication o Patent life into 2029 o Proprietary product, currently marketed by Alkermes in U.S. 1. LTM (last twelve months) as of 12/31/2010 COPYRIGHT © 2011 ALKERMES, INC. |
® BYDUREON o First once-weekly GLP-1 for type 2 diabetes o Long-acting version of Amylin s BYETTA® ($538 million LTM1 sales) o CHMP recommendation for approval in Europe on 4/15/2011, anticipated launch 2H 2011 o Planned U.S. resubmission 2H 2011 o Patent life into 2025 o Marketed by Eli Lilly and Amylin o 8% royalty rate 1. LTM as of 3/31/2011 COPYRIGHT © 2011 ALKERMES, INC. |
® RISPERDAL® CONSTA o Leading long-acting injectable antipsychotic for schizophrenia/bipolar I disorder o Approved in over 90 countries, $1.5 billion in end-market sales o Johnson & rd largest pharmaceutical brand by product revenues in 2010 o Patent life into 2020 in U.S., 2021 in Europe o 10% manufacturing and royalty rate, ~7.5% net o ~4% atypical antipsychotic market share in U.S. 1. LTM as of 12/31/2010 COPYRIGHT © 2011 ALKERMES, INC. |
® INVEGA® SUSTENNA® o Long-acting injectable antipsychotic for schizophrenia o First monthly depot schizophrenia drug o First commercialized NanoCrystal® depot product o Approved in U.S. and Europe, recent UK launch o Marketed by Johnson & Johnson o Patent life into 2019 o Tiered royalty rates on par with RISPERDAL® CONSTA® net economics COPYRIGHT © 2011 ALKERMES, INC. |
® Combined Pipeline: CNS Focus Reward Schizophrenia Depression Disorders Pain OIC MS ALKS 9070 ALKS 33/BUP ALKS 33 Meloxicam IV ALKS 37 AMPYRA® (binge eating) RISPERDAL® ZX002 CONSTA® ALKS 33 (alcohol ALKS 36 INVEGA ® dependence) SUSTENNA® ALKS 33/BUP (cocaine addiction) VIVITROL® COPYRIGHT © 2011 ALKERMES, INC. |
® Strong Strategic Fit at the Right Time o EDT positioned for growth; AMPYRA® and INVEGA® SUSTENNA® at beginning of their growth trajectories o Complementary world-class drug formulation and manufacturing expertise o CNS focused product portfolios - Royalties from long-acting atypical antipsychotics now under one roof o Capability to invest prudently in the strongest pipeline assets |
® EDT: Established Model for Profitability o 40-year history with >35 approved drugs o Commercial portfolio of 22 marketed drugs o NanoCrystal® and Oral Controlled Release technologies o Track record of innovation: AMPYRA®, AVINZA®, NAPRELAN® and VERELAN® o Diversified revenue streams Royalties on commercialized products - R&D revenues from partnered candidates Manufacturing revenues COPYRIGHT © 2011 ALKERMES, INC. |
® Deep Product Portfolio with Diversified Revenue Streams Products Mfg Rev Royalties ($MM) 300 Avinza® 274 Luvox® CR Diltiazem® Naprelan® Rapamune® 200 Ritalin ® LA / Focalin ® XR Verelan® Zanaflex ® Capsules 104 Emend® 100 Megace® ES Skelaxin® Tricor® 145 Recent Launches Mfg Rev Royalties 0 Ampyra® CY10 Invega® Sustenna® Revenue Adjusted EBITDA COPYRIGHT © 2011 ALKERMES, INC. |
® Key Transaction Terms Purchase Price Cash: $500 million Equity: 31.9 million shares (~25% of pro forma company) Combination of cash on balance sheet and prepayable new term loan Funding New debt of up to $450 million with secured financing from Morgan Stanley and HSBC Pro forma company immediately profitable on a cash earnings basis Financial Impact Immediately accretive to cash earnings Pro forma debt / Adjusted EBITDA of 4.6x to be reduced through future growth in EBITDA and debt paydown Synergies ~$20 million synergies to be Closing Conditions Alkermes shareholder approval Customary closing conditions and HSR clearance Shareholder Elan has entered into a shareholder agreement with respect to its Agreement holdings in the pro forma company Transaction Close Expected Q3 CY 11 |
® Alkermes plc: Financial Strength o Trailing 12 months as of March 31, 2011 Pro forma revenues ~$450 million Pro forma Adjusted EBITDA ~$80 million o Pro forma revenues Double-digit growth rates o Pro forma Adjusted EBITDA margins Expected to be in range of 15-20% in Expand to 30-35% in FY 13 and o $20 million in annual synergies in U.S. operations to be fully realized by COPYRIGHT © 2011 ALKERMES, INC. |
® Meaningful Increase in Revenues & Profitability Revenue Adj. EBITDA |
® Alkermes plc: Diversified Revenue Base (based on CY 10) |
® Alkermes and EDT: A Transformational Transaction Financially Operationally o Immediate profitability on a o Global biopharmaceutical cash earnings basis and company with proven track expanding Adjusted EBITDA record of innovation margins o Leader in CNS product o Accretive transaction development o Growing revenues in excess o Operating at a new scale of $450 million annually ~1,200 employees Driven by five major R&D expertise based on commercial products with proprietary technologies long patent lives World-class manufacturing o Incorporated in Ireland in U.S. and Ireland Accelerates profitability and provides springboard for growth COPYRIGHT © 2011 ALKERMES, INC. |
www.alkermes.com |