SECURITIES AND EXCHANGE COMMISSION
                             WASHINGTON, D.C. 20549

                      ------------------------------------

                                    FORM 8-K

                                 CURRENT REPORT
                       PURSUANT TO SECTION 13 OR 15(d) OF
                       THE SECURITIES EXCHANGE ACT OF 1934

       Date of Report (Date of earliest event reported): October 21, 2003

                              MKS Instruments, Inc.
-------------------------------------------------------------------------------
               (Exact name of registrant as specified in charter)

         Massachusetts                    0-23621               04-2277512
--------------------------------------------------------------------------------
(State or other jurisdiction of         (Commission            (IRS Employer
        incorporation)                  File Number)         Identification No.)


Six Shattuck Road, Andover, Massachusetts                          01810
--------------------------------------------------------------------------------
(Address of principal executive offices)                         (Zip Code)


       Registrant's telephone number, including area code: (978) 975-2350


--------------------------------------------------------------------------------
          (Former name or former address, if changed since last report)



ITEM 12. RESULTS OF OPERATIONS AND FINANCIAL CONDITION

     On October 21, 2003, MKS Instruments, Inc. announced its financial results
for the quarter ended September 30, 2003. The full text of the press release
issued in connection with the announcement is attached as Exhibit 99.1 to this
Current Report on Form 8-K.

     The information in this Form 8-K and the Exhibit attached hereto shall not
be deemed "filed" for purposes of Section 18 of the Securities Exchange Act of
1934 (the "Exchange Act") or otherwise subject to the liabilities of that
section, nor shall it be deemed incorporated by reference in any filing under
the Securities Act of 1933 or the Exchange Act, except as expressly set forth by
specific reference in such a filing.




                                    SIGNATURE

     Pursuant to the requirements of the Securities Exchange Act of 1934, the
Registrant has duly caused this report to be signed on its behalf by the
undersigned hereunto duly authorized.

Date: October 21, 2003                  MKS Instruments, Inc.

                                        By: /s/ Ronald C. Weigner
                                            ------------------------------------
                                            Ronald C. Weigner,
                                            Vice President & Chief Financial
                                            Officer


                                  EXHIBIT INDEX

Exhibit No.         Description
-----------         -----------
99.1                Press release dated October 21, 2003