MaxCyte Reports Fourth Quarter and Full Year 2022 Financial Results

ROCKVILLE, Md., March 15, 2023 (GLOBE NEWSWIRE) -- MaxCyte, Inc., (NASDAQ: MXCT; LSE: MXCT), a leading, cell-engineering focused company providing enabling platform technologies to advance the discovery, development, and commercialization of next-generation cell therapeutics and to support innovative, cell-based research, today announced its fourth quarter and full year ended December 31, 2022, financial results and provided initial 2023 revenue guidance.

Fourth Quarter and Full Year Highlights

  • Total revenue of $12.4 million in the fourth quarter of 2022, an increase of 22% over the fourth quarter of 2021.
  • Core business revenues grew 4% in the fourth quarter of 2022, with revenue growth from cell therapy customers growing 4% and revenue from drug discovery customers growing by 5%, over the fourth quarter of 2021.
  • Total revenue of $44.3 million for the full year 2022, an increase of 31% over the full year 2021.
  • Full year 2022 core business revenues grew 26%, led by cell therapy revenue growth of 33%, and revenue from drug discovery growing 8%.
  • Initial 2023 guidance for total revenue growth of 21% to 26% over 2022, including core revenue growth of 20% to 25% over 2022, and Strategic Platform License (SPL) program-related revenue of approximately $6 million.
  • Total cash, cash equivalents and short-term investments were $227.3 million as of December 31, 2022.

“We are pleased with our strong progress and performance in 2022 and look forward to continuing this positive momentum into 2023. Over the course of the year, we have made significant investments in our people, manufacturing capacity, and R&D infrastructure, which positions us well for our next stage of growth,” said Doug Doerfler, President and CEO of MaxCyte.

“Our portfolio of partnerships continued to grow throughout 2022, having announced three new SPL partnerships as well as the recent addition of Catamaran Bio as a partner in early 2023. We also entered into a partnership with Vertex following the transfer of the exa-cel program from CRISPR. The partnership maintains our role in this program, for which Vertex is currently seeking regulatory marketing approval in the United States and Europe for Sickle Cell Disease and Beta-Thalassemia. We are continuing to see our partners make strong progress across their clinical programs and are focused on providing them with the in-house manufacturing and regulatory support that they will require as they move towards commercialization. Our partnership pipeline remains robust and growing as we begin 2023 and we are excited to see our partners achieve upcoming milestones and move the cell therapy industry forward.”

The following table provides details regarding the sources of our revenue for the periods presented.

 Three Months Ended   Year Ended    
 December 31,
   December 31,
 2022    2021    %    2022    2021    % 
(in thousands, except percentages)                      
Cell therapy$7,544 $7,264 4% $30,546 $22,984 33% 
Drug discovery 3,026  2,885 5%  9,100  8,395 8% 
Program-related 1,854  3 NM*  4,616  2,515 83% 
Total revenue$12,424 $10,152 22% $44,262 $33,894 31% 

* Not Meaningful (NM)

Operational Highlights

  • Ended the year with 18 SPL partnerships, with the addition of partnerships with Intima Bioscience, LG Chem, and Curamys in 2022. With the addition of an SPL partnership with Catamaran Bio in early 2023, the total number of partnerships now stands at 19. Vertex Pharmaceuticals will use MaxCyte’s Flow Electroporation® technology and ExPERT™ platform to support the gene-edited hemoglobinopathy cell therapy exa-cel, formerly known under CRISPR as CTX001™. We entered into an SPL partnership with Vertex in 2022 for this transferred program. In addition, we retained our partnership with CRISPR therapeutics supporting CRISPR/Cas9-based therapies in immuno-oncology.
  • As of December 31, 2022, our 18 active SPL partner agreements allowed for over 125 potential programs; 16 of which were active programs currently in the clinic (defined as programs with at least a cleared IND or equivalent). If all potential programs successfully progress through the clinic to commercial approval, we estimate aggregate potential to generate pre-commercial milestone payments to us of over $1.55 billion in addition to sales-based commercial revenue due to us under existing agreements. At the end of 2021, there were 15 SPL partnerships covering over 95 programs with total potential pre-commercial milestones exceeding $1.25 billion. 
  • As of December 31, 2022, we had over 600 instruments placed with customers, compared to over 500 instruments at the end of 2021.
  • Launched the ExPERT branded VLx™, our large-scale Flow Electroporation platform.
  • Completed and occupied our new, 67,000 square foot, state of the art headquarters in Maryland’s I-270 biotech corridor, significantly increasing our in-house manufacturing capacity, as well as research and process development lab space.
  • Appointed Patrick J. Balthrop, Sr. to our board of directors as a non-executive member. Mr. Balthrop will also serve on the nominating and corporate governance committees of our board of directors.

In addition to revenue, management regularly reviews key business metrics to evaluate our business, measure performance, identify trends affecting our business, formulate financial projections and make strategic decisions. As of the dates presented, these key metrics were as follows:

  As of December 31, 
Installed base of instruments (sold or leased) >600>500>400
Number of active SPL partnerships 181512
Total number of licensed clinical programs (SPL partnerships only) >125>95>75
Total number of active licensed clinical programs under SPL partnerships currently in the clinic ** 16157
Total potential pre-commercial milestones under SPL partnerships >$1.55 billion>$1.25 billion>$950 million

* Amounts presented as of December 31, 2020, give effect to one SPL entered into and additional INDs cleared in January 2021.

** Number of licensed clinical programs under SPLs are by number of product candidates and not by indication.

Fourth Quarter 2022 Financial Results

Total revenue for the fourth quarter of 2022 was $12.4 million, compared to $10.2 million in the fourth quarter of 2021, representing growth of 22%.

Core business revenue (instruments and disposables to cell therapy and drug discovery customers and excluding program-related revenue) was $10.6 million in 2022, compared to core business revenue of $10.1 million in 2021, representing growth of 4%, including 4% revenue growth from cell therapy customers and 5% revenue growth from drug discovery customers.

Our SPL program-related revenue was $1.9 million in the fourth quarter of 2022 as compared to immaterial SPL program-related revenue in the fourth quarter of 2021.

Gross profit for the fourth quarter of 2022 was $10.9 million (88% gross margin), compared to $8.9 million (88% gross margin) in the fourth quarter of 2021.

Operating expenses for the fourth quarter of 2022 were $17.6 million, compared to operating expenses of $13.9 million in the fourth quarter of 2021. The overall increase in operating expenses was primarily driven by increases in R&D, sales, and marketing headcount and occupancy expenses related to our new corporate headquarters.

Net loss for the fourth quarter of 2022 was $4.8 million compared to net loss of $4.9 million in the fourth quarter of 2021. EBITDA, a non-GAAP measure, was a loss of $5.8 million for the fourth quarter of 2022, compared to a loss of $4.5 million for the fourth quarter of 2021; stock-based compensation expense was $3.1 million in the fourth quarter of 2022 compared to $2.4 million in the fourth quarter of 2021.

Full Year 2022 Financial Results

Total revenue for 2022 was $44.3 million, compared to $33.9 million in 2021, representing growth of 31%.

Core business revenue for 2022 was $39.6 million, compared to $31.4 million for 2021, representing growth of 26%, including 33% revenue growth from cell therapy customers and 8% revenue growth from drug discovery customers.

Our SPL program-related revenue for 2022 was $4.6 million, compared to $2.5 million in SPL program-related revenue in 2021, representing growth of 83% in 2022.

Gross profit for 2022 was $39.2 million (88% gross margin), compared to $30.2 million (89% gross margin) in the prior year.

Operating expenses for 2022 were $66.5 million, compared to operating expenses of $48.4 million in 2021. The overall increase in operating expenses was principally driven by increases in headcount, occupancy, and public company expenses.

Full year 2022 net loss was $23.6 million compared to a loss of $19.1 million in 2021. Full year 2022 EBITDA was a loss of $24.8 million compared to a loss of $17.4 million in 2021; total stock-based compensation for 2022 was $11.8 million, compared to $8.0 million for 2021.

Total cash, cash equivalents and short-term investments were $227.3 million as of December 31, 2022, compared to $255.0 million as of December 31, 2021.

2023 Revenue Guidance

Management is providing initial 2023 revenue guidance for total revenue, core business revenue and SPL program-related revenue.

Management expects full year 2023 total revenue growth of between 21% and 26% over 2022 including core business revenue growth of between 20% and 25% over 2022, and SPL program-related revenue of approximately $6 million.

Webcast and Conference Call Details

MaxCyte will host a conference call today, March 15, 2023, at 4:30 p.m. Eastern Time. Investors interested in listening to the conference call are required to register online. A live and archived webcast of the event will be available on the “Events” section of the MaxCyte website at

About MaxCyte

MaxCyte is a leading, cell-engineering focused company providing enabling platform technologies to advance the discovery, development and commercialization of next-generation cell therapeutics and to support innovative, cell-based research. Over the past 20 years, we have developed and commercialized our proprietary Flow Electroporation® technology, which facilitates complex engineering of a wide variety of cells. Our ExPERT™ platform, which is based on our Flow Electroporation technology, has been designed to support the rapidly expanding cell therapy market and can be utilized across the continuum of the high-growth cell therapy sector, from discovery and development through commercialization of next-generation, cell-based medicines. The ExPERT family of products includes: four instruments, the ATx™, STx™ GTx™ and VLx™; a portfolio of proprietary related processing assemblies or disposables; and software protocols, all supported by a robust worldwide intellectual property portfolio.

Non-GAAP Financial Measures

This press release contains EBITDA, which is a non-GAAP measure defined as earnings before interest income and expense, taxes, depreciation and amortization. MaxCyte believes that EBITDA provides useful information to management and investors relating to its results of operations. The company’s management uses this non-GAAP measure to compare the company’s performance to that of prior periods for trend analyses, and for budgeting and planning purposes. The company believes that the use of EBITDA provides an additional tool for investors to use in evaluating ongoing operating results and trends and in comparing the company’s financial measures with other companies, many of which present similar non-GAAP financial measures to investors, and that it allows for greater transparency with respect to key metrics used by management in its financial and operational decision-making.

Management does not consider EBITDA in isolation or as an alternative to financial measures determined in accordance with GAAP. The principal limitation of EBITDA is that it excludes significant expenses that are required by GAAP to be recorded in the company’s financial statements. In order to compensate for these limitations, management presents EBITDA together with GAAP results. Non-GAAP measures should be considered in addition to results prepared in accordance with GAAP, but should not be considered a substitute for, or superior to, GAAP results. A reconciliation table of net loss, the most comparable GAAP financial measure, to EBITDA is included at the end of this release. MaxCyte urges investors to review the reconciliation and not to rely on any single financial measure to evaluate the company’s business.

Forward-Looking Statements

This press release contains "forward-looking statements" within the meaning of the "safe harbor" provisions of the Private Securities Litigation Reform Act of 1995, including but not limited to, statements regarding expected total revenue growth, core business revenue growth and SPL program-related revenue for the year ending December 31, 2023, expansion of and revenue from our SPLs and the progression of our customers’ programs into and through clinical trials. The words "may," “might,” "will," "could," "would," "should," "expect," "plan," "anticipate," "intend," "believe," “expect,” "estimate," “seek,” "predict," “future,” "project," "potential," "continue," "target" and similar words or expressions are intended to identify forward-looking statements, although not all forward-looking statements contain these identifying words. Any forward-looking statements in this press release are based on management's current expectations and beliefs and are subject to a number of risks, uncertainties and important factors that may cause actual events or results to differ materially from those expressed or implied by any forward-looking statements contained in this press release, including, without limitation, risks associated with the timing of our customers’ ongoing and planned clinical trials; the adequacy of our cash resources and availability of financing on commercially reasonable terms; general market and economic conditions that may impact investor confidence in the biopharmaceutical industry and affect the amount of capital such investors provide to our current and potential partners; and demand for our products. These and other risks and uncertainties are described in greater detail in the section entitled "Risk Factors" in our Annual Report on Form 10-K for the year ended December 31, 2022, to be filed with the Securities and Exchange Commission on or about March 15, 2023, as well as in discussions of potential risks, uncertainties, and other important factors in the other filings that we make with the Securities and Exchange Commission from time to time. These documents are available under the “SEC filings” page of the Investors section of our website at Any forward-looking statements represent our views only as of the date of this press release and should not be relied upon as representing our views as of any subsequent date. We explicitly disclaim any obligation to update any forward-looking statements, whether as a result of new information, future events or otherwise. No representations or warranties (expressed or implied) are made about the accuracy of any such forward-looking statements.

MaxCyte Contacts:

US IR Adviser
Gilmartin Group
David Deuchler, CFA
+1 415-937-5400

US Media Relations
Seismic Collaborative, A Spectrum Science Company
Valerie Enes
+1 408-497-8568

Nominated Adviser and Joint Corporate Broker
Panmure Gordon
Emma Earl / Freddy Crossley
Corporate Broking
Rupert Dearden
+44 (0)20 7886 2500

UK IR Adviser
Consilium Strategic Communications
Mary-Jane Elliott / Chris Welsh
+44 (0)203 709 5700

MaxCyte, Inc.
Consolidated Balance Sheets

  December 31, 
     2022    2021
Current assets:        
Cash and cash equivalents $11,064,700  $47,782,400 
Short-term investments, at amortized cost  216,274,900   207,261,400 
Accounts receivable  11,654,600   6,877,000 
Accounts receivable - TIA  1,912,400    
Inventory  8,580,800   5,204,600 
Prepaid expenses and other current assets  2,778,800   3,307,400 
Total current assets   252,266,200    270,432,800 
Property and equipment, net  23,724,700   7,681,200 
Right-of-use asset - operating leases  9,853,500   5,689,300 
Other assets  809,000   316,700 
Total assets $ 286,653,400  $ 284,120,000 
Liabilities and stockholders’ equity        
Current liabilities:        
Accounts payable $531,800  $1,820,300 
Accrued expenses and other  8,025,300   6,523,500 
Operating lease liability, current  156,800   527,200 
Deferred revenue, current portion  6,712,600   6,746,800 
Total current liabilities   15,426,500    15,617,800 
Operating lease liability, net of current portion  15,938,100   5,154,900 
Other liabilities  1,321,600   450,200 
Total liabilities   32,686,200    21,222,900 
Stockholders’ equity        
Preferred stock, $0.01 par value; 5,000,000 shares authorized and no shares issued and outstanding at December 31, 2022 and 2021      
Common stock, $0.01 par value; 400,000,000 shares authorized, 102,397,913 and 101,202,705 shares issued and outstanding at December 31, 2022 and December 31, 2021, respectively  1,024,000   1,012,000 
Additional paid-in capital  390,818,500   376,189,600 
Accumulated deficit  (137,875,300)  (114,304,500)
Total stockholders’ equity   253,967,200    262,897,100 
Total liabilities and stockholders’ equity $ 286,653,400  $ 284,120,000 

* Tenant improvement allowance (“TIA”)

MaxCyte, Inc.
Consolidated Statements of Operations

     Three Months Ended December 31,  Year Ended December 31, 
  2022    2021    2022    2021
Revenue $ 12,423,600  $ 10,152,000  $ 44,261,500  $ 33,894,100 
Cost of goods sold  1,546,500   1,225,900   5,098,400   3,647,400 
Gross profit   10,877,100    8,926,100    39,163,100    30,246,700 
Operating expenses:                
Research and development  5,728,000   3,381,000   19,514,400   15,407,300 
Sales and marketing  5,376,900   4,089,400   18,652,900   13,002,900 
General and administrative  5,649,100   5,969,000   25,828,700   18,676,000 
Depreciation and amortization  873,300   441,900   2,527,600   1,349,100 
Total operating expenses   17,627,300    13,881,300    66,523,600    48,435,300 
Operating loss   (6,750,200)   (4,955,200)   (27,360,500)   (18,188,600)
Other income (expense):                
Interest and other expense  (10,900)  -   (126,900)  (1,044,400)
Interest income  1,951,700   80,800   3,916,600   150,800 
Total other income (expense)   1,940,800   80,800    3,789,700    (893,600)
Net loss $ (4,809,400) $ (4,874,400) $ (23,570,800) $ (19,082,200)
Basic and diluted net loss per share $ (0.05) $ (0.05) $ (0.23) $ (0.21)
Weighted average shares outstanding, basic and diluted   102,120,812   100,829,377    101,702,664    90,619,057 

MaxCyte, Inc.
Consolidated Statements of Cash Flows

     Year Ended December 31,
  2022    2021
Cash flows from operating activities:        
Net loss $(23,570,800) $(19,082,200)
Adjustments to reconcile net loss to net cash used in operating activities:      
Depreciation and amortization  2,697,900   1,423,900 
Net book value of consigned equipment sold  76,400   51,600 
Loss on disposal of fixed assets  139,500   32,500 
Fair value adjustment of liability classified warrant     645,400 
Stock-based compensation  11,752,400   7,958,800 
Amortization of discounts on short-term investments  (2,667,400)  (70,300)
Non-cash interest expense     5,400 
Changes in operating assets and liabilities:      
Accounts receivable  (4,777,600)  (1,705,100)
Accounts receivable – TIA  (1,912,400)   
Inventory  (3,493,300)  (1,405,800)
Prepaid expense and other current assets  528,600   (2,304,400)
Right of use asset – operating leases  (4,164,200)  (3,806,200)
Right of use asset – finance lease     63,500 
Other assets  (492,300)  (282,800)
Accounts payable, accrued expenses and other  (149,700)  2,090,900 
Operating lease liability  10,412,800   3,874,900 
Deferred revenue  (34,200)  1,903,800 
Other liabilities  871,400   (73,500)
Net cash used in operating activities  (14,782,900)  (10,679,600)
Cash flows from investing activities:        
Purchases of short-term investments  (290,942,100)  (268,683,600)
Maturities of short-term investments  284,596,000   77,500,000 
Purchases of property and equipment  (18,477,200)  (3,834,200)
Proceeds from sale of equipment     4,600 
Net cash used in investing activities  (24,823,300)  (195,013,200)
Cash flows from financing activities:        
Net proceeds from issuance of common stock     51,808,900 
Net proceeds from issuance of common stock upon initial public offering     184,268,400 
Principal payments on notes payable     (4,922,400)
Proceeds from exercise of stock options  2,888,500   3,631,200 
Principal payments on finance leases     (66,100)
Net cash provided by financing activities  2,888,500   234,720,000 
Net (decrease) increase in cash and cash equivalents  (36,717,700)  29,027,200 
Cash and cash equivalents, beginning of year  47,782,400   18,755,200 
Cash and cash equivalents, end of year $11,064,700  $47,782,400 

Unaudited Reconciliation of Net Loss to EBITDA

 Three Months Ended Year Ended
 December 31, December 31,
 2022    2021    2022    2021
(in thousands)               
Net loss$(4,809) $(4,874) $(23,571) $(19,082)
Depreciation and amortization expense 920   417   2,698   1,424 
Interest (income) expense, net (1,952)  (81)  (3,917)  239 
Income taxes           
EBITDA$(5,842) $(4,538) $(24,789) $(17,419)

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