Kairos Pharma (NYSE American: KAPA), a clinical-stage biopharmaceutical company, announced completion of the safety lead-in for its Phase 2 trial evaluating ENV105 in combination with apalutamide for metastatic, castration-resistant prostate cancer. The trial will now proceed with patient randomization to assess apalutamide alone versus the combination therapy. Safety and efficacy data from the lead-in phase are expected in the first half of 2025. The company is also validating biomarkers to identify patients most likely to benefit from ENV105 and continues enrollment at cancer centers in Los Angeles and Salt Lake City.
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About Kairos Pharma Ltd.
Based in Los Angeles, California, Kairos Pharma is at the forefront of oncology therapeutics, utilizing structural biology to overcome drug resistance and immune suppression in cancer. Its lead candidate, ENV105, is an antibody that targets CD105—a protein identified as a key driver of resistance to various cancer treatments. Elevation of CD105 in response to standard therapy results in resistance and disease relapse. ENV105 aims to reverse drug resistance by targeting CD105 and restore the effectiveness of standard therapies across multiple cancer types. Currently, ENV105 is in a Phase 2 clinical trial for castrate resistant prostate cancer and a Phase 1 trial for lung cancer, addressing significant unmet medical needs. For more information, visit the company’s website at www.KairosPharma.com.
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